00:00
So as far as knowing
what the causes are,
here's what we know so far.
00:05
It's a combination of genetic
and environmental factor.
00:09
So if certain people
who have this genetic
code in their body
most commonly white
males aged 15 to 35,
they have this genetic
code in their body
if they're exposed to the
right environmental factors,
they could develop the syndrome.
00:25
Now,
we say environmental factors
that could be like
smoking or other chemicals
that your body is exposed to.
00:31
But put this unknown
environmental factor
together with your
genetic layout
and you've got a risk for
goodpasture's syndrome.
00:39
Now, let's look at some examples
of other environmental factors.
00:42
We already talked
about smoking cocaine.
00:45
Yes, believe it or not.
00:47
That's an environmental factor.
00:48
Now this probably isn't
what's on most people's mind
if there were trying cocaine
but it is a known risk of that.
00:54
They can have inhaled
hydrocarbons, lung infections,
metallic dust or
chemical exposure
even some medications can
attack the immune system.
01:04
Like can you say
that one right there?
Look at that.
01:07
We're just about yeah,
that's a fun one.
01:09
You need to Google that one
for the correct pronunciation.
01:13
So why are we looking
at these six boxes
about goodpasture's syndrome?
Well, we know that it is a
combination of genetic factors.
01:21
Remember it's rare usually
most common in males
that are white 15
to 35 years of age.
01:28
So we're looking at
the genetic component
plus environmental factors.
01:33
Now if I was
studying for an exam,
I memorize these six things?
No, I really wouldn't.
01:38
I would just think about taking
things into my body
that are hurtful.
01:43
That's it.
That's as far as we would go.
01:45
Now, I have some
specific things here
just to kind of lay
that down in your mind,
but don't use your brain space
to memorize these six things
just think environmental
factors taking things
in that are harmful to my body.
01:59
Whoa, that's kind of
an intense question.
02:02
Isn't it?
Is it fatal?
Well, it's a fair question.
02:06
Patients can die from this
but usually they don't.
02:10
Here's the best way
to prevent that.
02:12
They need acute treatment
appropriate acute treatment
in the middle of it.
02:16
We need to help reduce
their risk factor exposure
and we need to help them
with follow-up care.
02:21
So if we can have all
three of those in place
your patient should be fine
and should not die from
this autoimmune disease.
02:29
So if you want to help a
patient with this syndrome,
what do we need to follow?
Make sure they get
acute treatment quickly,
we learn about what their risk
factors are for each patient.
02:40
Now, you know that this is
caused by genetic factors
and environmental factors.
02:45
So we'd have to do some
very cautious investigating
because remember this
can be a sensitive topic.
02:51
Most people who smoke
know that it's
not great for you,
but it's a really
tough habit to quit.
02:57
So if you determine
that one of the environmental
risk factors are being exposed
to smoking no judgment.
03:03
Just help the patient understand
how their life could be better
if they can wean
themselves off this habit
and hopefully stop completely
so they need support
and education because it
is a tough habit to kick.
03:17
So you want aute treatment
you want to help them
reduce the risk factors
and if it's an obvious
one like smoking,
then we can help them
and give them support
or it might take a look
at what they're exposed
to it their job,
might take extra
step to figure out
what those environmental
factors are
and they'll need follow-up care
Now sadly the next topic
for patients that
do die from this.
03:39
It's usually
pulmonary Hemorrhage
that's the most common
cause of an early death
for patients with this disease.
03:45
So majority of them
do not die if they get acute
treatment that's appropriate.
03:50
We reduce the risk factors
and we have appropriate
follow-up care for them.
03:54
If the patient does die
the most common causes
pulmonary hemorrhage.
03:59
And now it's not a
pretty death because
if you think about that
what's going to happen
with the patient
as they go into
respiratory failure
because the lungs
cannot function
because that extra blood
actually in the tissue.