00:01 The glomerular filtration rate is the volume of filtrate form permanent by both kidneys. 00:08 This is normally about a 120 to a 125 milliliters per minute. 00:15 The glomerular filtration rate or GFR is directly proportional to the net filtration pressure where the primary pressure is going to be our glomerular hydrostatic pressure. 00:28 Also, the GFR is proportional to the total surface area available for filtration. 00:36 Here, the glomerular mesangial cells are going to control this surface area by contracting. 00:44 Finally GFR is directly proportional to filtrate membrane permeability. 00:50 Which is much more permeable than the other capillaries that we find throughout the body. 00:58 A constant GFR is important as it allows for our kidneys to make a filtrate and maintain our extra cellular homeostasis. 01:08 The goal of local intrinsic controls are renal autoregulation is to maintain this GFR in our kidneys. 01:18 Our GFR also affects our systemic blood pressure. 01:22 An increased GFR causes an increased urine output with lower blood pressures and vice versa. 01:31 Also, we have extrinsic controls which are necessary to maintain our systemic blood pressure. 01:38 Our nervous system and our endocrine system are going to be the main extrinsic controls of the kidney.
The lecture Glomerular Filtration Rate (GFR) – Urine Formation (Nursing) by Jasmine Clark, PhD is from the course Urinary System – Physiology (Nursing).
Why is a constant glomerular filtration rate (GFR) important?
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