00:01
Now let's look at the eGFR
that stands for estimated
glomerular filtration.
00:06
You can't really it's pretty
complex to do an actual GFR.
00:10
That's why we use an estimate
includes the serum creatinine.
00:14
Now it's impacted
by lots of things.
00:16
So your GFR is impacted
by how old you are
the older you get
the lower it gets.
00:23
Sex in body size
also play a role.
00:27
So it's usually higher for
men than it is with women.
00:30
And and it decreases with age.
00:33
Okay,
let me pause for just a minute.
00:34
So the estimated
glomerular filtration rate
we're talking about the rate that
that glomerulus is functioning, right?
Usually higher in men than women
and it decreases with age.
00:47
130 milliliters a minute is what
you'll see in men, 120 for women.
00:53
So we remember,
men serum creatinine
was a little bit higher
and also their GFR is
a little bit higher
just to keep that in mind.
01:01
Why do we care?
Well, this is how we
kind of communicate
amongst each other as
Healthcare Providers
about what stage of kidney
impairment the patient is at.
01:11
Now if the GFR is greater
than 90 that's just stage one.
01:15
It's normal or a high GFR.
01:16
Okay stage 2.
01:18
Oh, hey, let me tell you
do not memorize these,
this is just to give you a
concept of this is one of the ways
that we use GFR.
01:26
I would not recommend
getting ready for a test
that you would have these.
01:30
Straight up memorized.
01:31
I just want you to have this
as a frame of reference.
01:34
So you've got stage one
and see how the kidney
is mostly dark grey
with just a little bit
of like right on the top.
01:41
Stage 2.
01:41
We consider that mild
chronic kidney disease,
Their GFR is running
about 60 to 89.
01:47
Now stage 3 has an A and B,
see 45 to 59 or 30 to 44.
01:54
So see how the kidney the
gray area is getting larger
in the kidney to help
your brain recognized.
02:00
That stage 3 is definitely
worse than stage 1.
02:04
You have a lower and slower
glomerular filtration rate
in stage 3 that you
would in stage 2.
02:10
So if you thought stage 3 was
problematic look at stage 4.
02:14
What's the GFR in stage 4 for
severe chronic kidney disease,
Right. 15 to 29.
02:22
Now think back.
02:23
What is the normal GFR
for a man or for a female?
Yeah, definitely above a hundred
even if you didn't
remember that.
02:34
Stage 5 is really
severe circumstances.
02:38
This is end-stage
chronic kidney disease.
02:41
You have a GFR
that's less than 15.
02:45
So this is someone who's
probably needing some other type
of severe kidney intervention,
dialysis, peritoneal
dialysis, hemodialysis.
02:53
We're having to do something
major at this point
because the kidneys are not
able to keep the patient safe.
02:59
So major takeaway
points from this slide.
03:02
We look at stages
of chronic kidney disease
from stage 1 to Stage 5.
03:08
The higher the number
the lower the GFR.
03:11
That's the main concept.
03:12
We want you to take
away from this.
03:14
Now, beyond GFR remember
it's an estimate
to what degree and extend the
kidney function is impaired
and will help us know
what we should do
as we're following the
progression of the disease.
03:24
The GFR doesn't tell us
how the kidneys
were damaged or why.
03:29
It just tells us mmm,
here's how the
kidneys are function
much like a blood pressure.
03:35
If we take a blood pressure,
We're going to get a reading
and it's going to tell us
if your blood pressure
is high low or normal,
but it doesn't tell
us why it's high
doesn't tell us why it's low,
doesn't tell us why it's normal.
03:45
We have to do some further
investigating for an abnormal reading.
03:49
Same thing with GFR.
03:51
It tells us "Excuse me.
You got a problem."
"Stage 4,
You got a real big problem."
"Stage 1, Let's pay attention
and see if we can really
help the patient make
any lifestyle changes
and the physician will
prescribe medications
that may also help us prepare
delay the progression
of the disease.
04:07
So if we're looking
at an overall picture
of a patient's kidney function,
they'll look at a
full urine analysis,
they'll measure urinary
protein excretion.
04:18
And if necessary,
they'll do some real logical studies
or some a kidney biopsy.
04:22
So that is some
hardcore assessments.
04:26
Your analysis all
the parts of it.
04:28
Look at at urinary
protein excretion
and if it's necessary to figure
out what exactly is going on,
we'll look at radiologic studies
and or do a kidney biopsy.
04:39
I want to talk a little
bit more about GFR and
what a normal GFR represents.
04:44
Now, we know the actual GFR
is really hard to measure
so we use an estimate.
04:49
That's when you see that
little "e" in front of the GFR.
04:52
Now in order to calculate it
we use the serum creatinine,
patients age,
patient's body size
and their gender.
04:59
Now take a look at that dial.
05:01
You see we've got
three main sections.
05:04
Over on the right,
You've got between 60 and 120
that's considered a normal GFR.
05:10
Kidney disease is
when the GFR drops lower than 60
and in fact actual numbers
aren't even reported
until the eGFR is less than 60.
05:20
So if you don't see a
number that's probably
because it is higher than 60
Now over in the red.
That's the really sad part.
05:28
Less than 15 GFR that means
we're in kidney failure.
05:32
So this patient is having to
have some major interventions
like peritoneal dialysis
or hemodialysis.
05:38
So this was put here just
to kind of give you an idea
of what we're looking at.
05:43
Rather than memorizing all
these different categories.
05:46
This may be a much
more simpler way
for you to approach eGFR.
05:49
Know that it doesn't even get
reported until less than 60.
05:53
That's when we say,
through kidney disease is
kind of started to kick in
once we get lower
than 15 that's severe
kidney failure.
06:02
So I would remember
less than 60 starts to be
a problem less than 15.
06:06
That is severe kidney failure.