Fusion Inhibitors – HIV Drugs (Nursing)

00:00 Okay.

00:01 So let's look at this cycle.

00:03 First of all, if you like to have room ahead we've got four cycles or stages that we're going to talk about in this life cycle.

00:10 The first one is binding infusion.

00:12 The next one is conversion and integration, third is replication and forth is assembly budding and maturation.

00:20 So what you're looking at here are the stages, the four stages of the HIV life cycle.

00:28 Okay, cool.

00:29 We've got some graphics for you there.

00:30 But I'm going to help you recognize what the most important parts are.

00:34 We're going to start with the first stage.

00:36 I know clever, but that's where we're going to start.

00:39 So binding and fusion.

00:41 That's the first stage the virus attaches itself to the T helper cell and releases HIV into the cell.

00:49 That's the binding and fusion.

00:51 So drugs that work, they are called HIV Fusion Inhibitors.

00:57 So make sure you write that down go back up to your slide with the four stages and write in HIV Fusion inhibitor.

01:05 Now give you an example of that drug in just a minute, but I want you to have the concept if we can stop that Fusion.

01:11 Ah, then you can see why we have less viral right? Because if I stop the fusion I'm not going to have steps 2, 3 and 4, so I'm not going to have extra copies being released into the system.

01:23 Cool! So fusion or entry inhibitor drugs stop this from happening.

01:29 So that's stopping it very early in the process before we've gone through the other phases.

01:35 So here's an example of one of the medications.

01:38 Make sure you circle that drug name up there because that's one, I think it's really important that you recognized as an example of this type of medication.

01:46 So it's an HIV Fusion inhibitor.

01:49 It's widely known as T20.

01:52 So right that back in up at the top by the name just to remind you that this one is often called T20.

01:59 It's the first and only only HIV fusion inhibitor and it blocks HIV from getting into the CD4 T-cells and it's twice daily.

02:09 Oh oh! SubQ dosing.

02:12 Okay as a health care provider, you know what that means right as I'm part of the team.

02:17 I have to think about twice a day.

02:19 This patient has to have the medication accessible to them and they have to be comfortable with giving themselves a SubQ injection.

02:27 Well think back to first day of clinical lab when you to do this on a partner.

02:32 It was nerve-racking right in want to hurt them.

02:35 Well, some people can stick other people all day long, but when it comes to sticking themselves, that's another issue.

02:43 So this will involve you being very patient with the patient assessing how comfortable they feel with the process of sticking themselves with a SubQ needle how comfortable are they had drawing up medication Etc and Etc.

02:56 Can they see the syringe? Do they have the hand dexterity to do that? Do they have any issues with arthritis and I have a difficult time with the syringe on and on so it's not just enough to tell a patient, Yeah, this is what you do.

03:11 As a nurse I'm always thinking, are they capable of doing this? Do they have the resources to do this? Are they ready to do this emotionally physically mentally.

03:20 Now usually this is a pretty small adjustment but it's still an adjustment don't overlook that with your patients.

03:28 So you've got these stages.

03:29 We just talked about this drug, T20.

03:31 It's in the binding and the fusion stage, right? So the adverse effects can be injection site reactions, you know again teach the patient how to rotate the site's what sites are going to be most easily accessible for the patient, but help them to know that injection site reactions sometimes happen.

03:48 If they experience that just let us know and we'll work with them and problem-solve.

03:54 Now there's also an increased risk for pneumonia and it's a hypersensitivity reactions inhibitor.

04:00 I know those are kind of weird but those are the three major ones we'd be looking for with T20.