Follicle Development (Nursing)

by Jasmine Clark, PhD

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    00:01 So now let's take a closer look look at the ovarian cycle.

    00:06 The ovarian cycle is approximately a monthly or 28-day series of events that are associated with the maturation of an egg or ovum.

    00:20 There are two consecutive phases that are going to occur in the ovarian cycle with ovulation being the midpoint between these two phases.

    00:32 The first phase of the ovarian cycle is the follicular phase.

    00:37 This is a period of vesicular follicle growth and occurs between days 1 through 14 of a 28-day cycle.

    00:47 The second phase and the ovarian cycle is the luteal phase.

    00:52 This is a period where the corpus luteum is active.

    00:56 This occurs in days 14 through 28 of a 28 day cycle.

    01:04 Only about 10 to 15 percent of females have a 28 day cycle.

    01:11 While the first follicular phase can vary in women.

    01:16 The luteal phase is always 14 days from ovulation to the end of a cycle.

    01:25 So let's take a closer look at the first phase of the ovarian cycle the follicular phase.

    01:32 Starting with the development of the follicle.

    01:36 So in this phase, a primordial follicle is going to become the primary follicle.

    01:43 Squamous-like cells surrounding the primary oocyte will become cuboidal and the oocyte will begin to become larger.

    01:53 This process can take about one year.

    01:57 Now this follicle is known as the primary follicle.

    02:04 So now that the primordial follicle has become the primary follicle, the follicular cells are going to proliferate forming a stratified epithelium around the oocyte.

    02:18 When more than one layer of cells are present, we now refer to these follicular cells as granulosa cells.

    02:26 And now the primary follicle is referred to as the secondary follicle.

    02:33 At this point the granulosa cells and the oocyte are going to guide one another's development via gap j unction connections between the two.

    02:44 In the secondary follicle, connective tissue and granulosa cells are going to condense in order to form the theca folliculi.

    02:55 Also, we have the formation of the zona pellucida, which is a thick glycoprotein rich membrane that is secreted by the oocyte encapsulating the oocyte within it.

    03:09 Early vesicular follicles are formed when a clear liquid begins to accumulate between the granulosa cells as they secrete follicular fluid.

    03:22 This fluid builds up in a large cavity known as the antrum.

    03:28 Once you have antrum formation, we are now going to refer to this as the vesicular follicle because it looks like a large vesicle.

    03:38 This is going to distinguish it from the previous follicles or the pre antral follicles versus the antral follicles.

    03:48 The antrum is going to continue to expand with this follicular fluid further isolating the oocyte.

    03:57 At this point, the oocyte is surrounded by the zona pellucida and the granulosa cells.

    04:04 These granulosa cells are now referred to as the corona radiata.

    04:12 The corona radiata sits on a stalk on one side of the follicle.

    04:19 When the follicle is at full-size it begins to bulge from the external ovary surface.

    04:27 At this point, the follicle is ready to be ovulated and it is now referred to as the mature or graafian follicle.

    04:38 To recap, if we compare the events of meiosis with the development of the follicle, we find that before birth we have our primordial follicles in the ovaries.

    04:50 In the follicle, in the primordial follicle, we have our oogonia, which are going to eventually go through mitosis to form primary oocytes.

    05:03 Throughout infancy and childhood, our primary oocytes going to be preparing for the divisions that will happen in puberty.

    05:13 Also, the primordial follicle will be preparing or just waiting as well.

    05:19 Once we hit puberty the primary oocyte is going to complete meiosis 1 forming the secondary oocyte and the first polar body.

    05:30 This occurs, in the secondary and eventually the vesicular follicle.

    05:36 The secondary oocyte is released during ovulation where it is arrested in metaphase 2.

    About the Lecture

    The lecture Follicle Development (Nursing) by Jasmine Clark, PhD is from the course Female Reproductive System – Physiology (Nursing).

    Included Quiz Questions

    1. The follicular cells proliferate, forming stratified epithelium around the oocyte
    2. Granulosa and oocytes guide development through gap junctions
    3. The early vesicular follicle is formed between granulosa cells
    4. The antrum forms when fluid coalesces around the oocyte
    1. It completes meiosis I, forming the secondary oocyte and the first polar body
    2. It completes meiosis I and II and forms the secondary oocyte
    3. It completes mitosis and meiosis I and forms the secondary oocyte and the first polar body
    4. It completes mitosis and forms the first and second polar bodies

    Author of lecture Follicle Development (Nursing)

     Jasmine Clark, PhD

    Jasmine Clark, PhD

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