Folate Metabolism Overview and Health

by Kevin Ahern, PhD

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    So I said folate is can sort of be recycled among each other and now I want to spend some time talking about how that recycling process between different folate molecules actually occurs. We start this process looking at the very bottom of the screen where we start with the tetrahydrofolate that we’ve been talking about so far. Tetrahydrofolate can be converted into the methylene form, the N5, N10 methylene form that I described earlier via the serine/glycine metabolism, reactions that we saw earlier. These reactions add in the direction of the methylene. They add methylene group between those two nitrogens as we saw before by converting serine to glycine. The methylene form can be converted into a methyl form by reduction as we can see in the next slide and that reduction requires electrons from NADPH. That produces the N5 methyl group. We can see that we now have a methyl group in place of the methylene group that we had before. The methionine synthesis, of course, uses this N5 methyl THF to be able to produce the THF that we saw earlier. And this will be closed to the cycle on that round of the folate molecules. The N5, N10 methylenetetrahydrofolate can also be converted into a group of other folates as we can see here. That happens if it gets oxidized. So oxidation of that methylene group, donating electrons into NADP to make NADPH produces this N5, N10 methenyltetrahydrofolate or THF as you can see on the screen. This molecule has now this carbon double bonded to the nitrogen as you can see. The restructuring of that molecule produces another folate known as the N5 formyl tetrahydrofolate as shown and the formyl group is shown in the blue box contrasted with the methenyl group that we’ve shown...

    About the Lecture

    The lecture Folate Metabolism Overview and Health by Kevin Ahern, PhD is from the course Vitamins. It contains the following chapters:

    • Folate Metabolism Overview
    • Folate and Health

    Author of lecture Folate Metabolism Overview and Health

     Kevin Ahern, PhD

    Kevin Ahern, PhD

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