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Folate Metabolism and Recycling

by Kevin Ahern, PhD
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    About the Lecture

    The lecture Folate Metabolism and Recycling by Kevin Ahern, PhD is from the course Vitamins. It contains the following chapters:

    • Folate Metabolism
    • Folates in Purine Metabolism and in Thymidylate Synthesis
    • Folate Recycling

    Included Quiz Questions

    1. Folate deficiency leads to excessive hemorrhage in the adults
    2. Folic acid is given to the pregnant women as a supplement to prevent the neural tube defects
    3. Folic acid is an essential vitamin and is required for synthesis of nucleic acids and amino acid metabolism
    4. Folate deficiencies lead to severe megaloblastic anemia in adults
    5. Vitamin B9 plays an essential role in the synthesis of thymidine from the uridine containing nucleotides
    1. Single-carbon transfer reaction
    2. Two-carbon transfer reactions
    3. Three-carbon transfer reaction
    4. Nitrogen-containing ring transfer reactions
    5. Cyclic hydrocarbon transfer reactions
    1. Tetrahydrofolate reductase enzyme inactivation messes with the nucleotide metabolism in cancer cells and hence leads to their killing
    2. Tetrahydrofolate reductase enzyme inactivation messes with the cell membrane synthesis in cancer cells and hence leads to their killing
    3. Tetrahydrofolate reductase enzyme inactivation messes with the cell membrane structure maintenance in cancer cells and hence leads to their bursting
    4. Tetrahydrofolate reductase enzyme inactivation messes with the nuclear membrane structure maintenance in cancer cells and hence leads to whole cell disintegration
    5. Tetrahydrofolate reductase enzyme inactivation messes with the spindle formation at the time of cell division in cancer cells and hence leads to slow cell death
    1. Dihyrofolate reductase enzyme which participates in the regeneration of tetrahydrofolate from dihydrofolate
    2. Dihyrofolate reductase enzyme which participates in the regeneration of dihydrofolate from tetrahydrofolate
    3. Dihyrofolate oxidase enzyme which participates in the regeneration of tetrahydrofolate from dihydrofolate
    4. Dihyrofolate oxidase enzyme which participates in the regeneration of dihydrofolate from tetrahydrofolate
    5. Dihyrofolate carboxylase enzyme which participates in the regeneration of dihydrofolate from tetrahydrofolate

    Author of lecture Folate Metabolism and Recycling

     Kevin Ahern, PhD

    Kevin Ahern, PhD


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