Folate Metabolism and Recycling

by Kevin Ahern, PhD

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    Folates are important compounds that donate one carbon units to individual biochemicals that are being synthesized. And we will see how that occurs here. So folates are involved in single carbon transfer reactions. They are sometimes called vitamin B9, although more commonly refer to them as folic acid or folates. Deficiencies of folates in our diet can be very severe, resulting in megaloblastic anemia in adults, cardiovascular disease, birth defect in infants, particularly failure to close the neural tube during the process of development. And these problems overcome to a large extent in recent years by supplementation of folates in grains. It's things such as our bread now contains folate that didn’t contain folates before. You can see two of different folates on the right and as we'll see, this is a whole family of compounds but slightly different structures involved in adding different forms of one carbon units to build a biochemical molecule. There are many different forms of folate as I noted and they can differ in both their oxidation state and also in the configuration of carbons they have to allow diversity of forms of one carbon units that can be added to a growing biochemical molecule. Now, folates are important in many metabolic processes. We see them, for example, as required in the synthesis of purine nucleotides for making RNA and DNA. They’re also necessary for making thymidine from the uracil containing nucleotides. We've seen how they’re involved in other lectures here in the synthesis methionine. And they’re also important for the interconversion of serine and glycine in the metabolism of those two vitamins. You can see two different forms of folates: the N5, N10 methylenetetrahydrofolate on top and the 5-methyltetrahydrofolate on the bottom. Now, if we look at the serine and glycine metabolism, we see...

    About the Lecture

    The lecture Folate Metabolism and Recycling by Kevin Ahern, PhD is from the course Vitamins. It contains the following chapters:

    • Folate Metabolism
    • Folates in Purine Metabolism and in Thymidylate Synthesis
    • Folate Recycling

    Author of lecture Folate Metabolism and Recycling

     Kevin Ahern, PhD

    Kevin Ahern, PhD

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