by Thad Wilson, PhD

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    Once you have the sperm arrive to where the egg is, this is usually in the ampulla region of the fallopian tubes, although it can occur elsewhere but that is the typical locale. The fertilization process is multiple step in nature. To do this, we will take these steps one at a time as we go through looking at this overall response. The sperm, I think, you can recognize here in the picture. The egg is the purple shape with the couple rings around it. The rings are important when I go through the explanation because there are the different layers of the egg and those color layers will be retained to all the different pie chart diagrams that you see. Let's start with the first step of fertilization. In this particular step, the sperm just needs to get close enough to the egg. It has a special matrix around the egg that it needs to get through and it does this with the special protein called PH-20. This PH-20 allows for the sperm to get close enough to even touch the egg. At this point, the sperm is going to have to try to break through these couple layers of the egg. The first one is the zona pellucida. This zone is very important. This is the first protective layer that the sperm needs to get through. There are a few different receptors and glycoproteins that need to have an interaction take place. So the sperm needs to bind to ZP3 portions on the zona. At this point, it has specific receptors that are being expressed after that capsule change that happened on the trip in. If it has these aligned ZP3 receptors to these glycoproteins on the membrane, you'll have a binding take place. Then after the binding...

    About the Lecture

    The lecture Fertilization by Thad Wilson, PhD is from the course Reproductive Physiology.

    Author of lecture Fertilization

     Thad Wilson, PhD

    Thad Wilson, PhD

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