00:01
So let's talk about
epilepsy,
and how we make
an epilepsy diagnosis?
And what the different types
of epilepsy are?
The International
League Against Epilepsy,
which is the largest
governing body,
defines epilepsy syndromes as
complex set of signs and symptoms
that defines a
unique epileptic condition.
00:19
Well, that's a lot of words
that don't mean a whole lot
to we as clinicians,
or test takers
looking at clinical vignettes.
00:26
So when I'm thinking
about epilepsy,
I think of a constellation.
00:30
That includes
the type of seizures,
the EEG findings,
the age of onset
of the patient,
which is very important in making
the right epilepsy diagnosis.
00:40
The course of the epilepsy,
whether it resolves spontaneously
or becomes progressive.
00:47
Any associated clinical features,
either cutaneous findings
on their general exam,
or neurologic findings
on their neurologic exam.
00:55
And then we think about
the underlying pathophysiologic,
or genetic mechanisms
that may cause certain
epilepsies, and not others.
01:03
And when we put all of these
six features together,
we can make a precise diagnosis
of the type of epilepsy
that a patient may be suffering.
01:14
With, when we think more
specifically about classification,
I'd like for you
to think about two things
that contribute to the
classification of the epilepsy
that help us determine,
what type of epilepsy it is?
The first is the EEG,
that's one of those six criteria,
and maybe one of the most important.
01:31
EEGs tend to show
generalized onset seizures
or localization related seizures,
or focal-onset seizures.
01:38
An epilepsy is tend to be
generalized or focal
and how we describe them.
01:43
The second is I'd like to,
for you to think about the etiology.
01:47
Is this an idiopathic epilepsy
that doesn't have a cause?
Or is this a symptomatic,
or secondary form of epilepsy
that comes from someone
other underlying insult?
Categorizing epilepsies
in this way,
can be extremely helpful.
02:02
We have certain anti-epileptics
that are better for
generalized seizures,
and others for focal seizures.
02:07
And so there's a
treatment implication
to making a diagnosis
based on these EEG findings.
02:13
In addition,
this helps us with prognosis.
02:15
It tends to be that symptomatic
or secondary epilepsies
that come from
some underlying cause
have a worse prognosis.
02:22
are more medication refractory,
and may result in early death
than the idiopathic
primary epilepsies.
02:31
In this lecture,
we're going to talk about
a few of the most common
epilepsy syndromes.
02:35
There are many out there,
but we're going
to review the ones
that you may see clinically,
or maybe encountered
on a clinical vignette.
02:43
And as we talked about,
we can categorize them
as generalized in onset
or focal-onset,
and idiopathic or symptomatic.
02:51
So the three seizure types
in epilepsy syndromes
that we'll talk about,
that have a
generalized-onset epilepsy
and are idiopathic
are childhood absence,
juvenile absence,
and juvenile myoclonic epilepsy.
03:03
These are idiopathic
we don't know why they occur.
03:06
There's not an underlying insult
that causes them.
03:09
And the seizures tend to be
generalized and onset.
03:12
And that will help us
with treatment decisions.
03:15
The focal-onset epilepsy
that's also idiopathic,
that we'll review as
benign childhood epilepsy
with centrotemporal spikes,
which is called BECTS.
03:24
This is important idiopathic,
it doesn't have a cause
epilepsy syndrome,
where the seizures
are focal in onset.
03:32
And then we'll review some
important symptomatic epilepsies.
03:35
West syndrome and
Lennox-Gastaut syndrome,
are probably two
of the most important
symptomatic or secondary
generalized epilepsy syndromes.
03:43
They have a cause some
underlying neurologic insult
that drove the onset of seizures
and other neurologic dysfunction.
03:51
And then the symptomatic
focal-onset epilepsy
will review as
temporal lobe epilepsy.
03:55
Then this is one of the more
common epilepsies
particularly
that we see in adults.
03:58
And it's important to understand
from a treatment standpoint.