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Epidermal Growth Factor Receptor (EGFR)

by Kevin Ahern, PhD
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      Slides HormonesSignalTransduction Biochemistry.pdf
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    The next receptor system I’d like to talk about is that of the epidermal growth factor receptor or the EGFR. Like the other receptors I’ve been talking about, the epidermal growth factor receptor is a receptor tyrosine kinase. It dimerizes on binding to epidermal growth factor or EGF. Now EGF is a protein that’s involved in the growth and proliferation of cells. And EGF helps to control that overall process. So let’s take a look at the signaling pathway up close. We see on this figure, the binding of EGF shown in green, on the outside part of the cell to the EGF receptor. The receptor here has dimerized and is holding that EGF in the cell membrane. We can see some accessory proteins that have come along and have started to form the signaling complex on the inside of the cell. This includes a protein known as GRB2. And GRB2 is binding to phosphoytyrosines that are on the cytoplasmic side of the cell, on the EGF receptor. That autophosphorylation that I described before has happened here. And this GRB2 has an SH2 domain that recognizes those phosphoproteins and binds to them. GRB2 binds to another protein known as SOS, which for our purposes here is insignificant. But what is significant is the next protein that binds which is known as RAS. Now RAS is a protein that’s very intimately involved in controlling the cell’s decision to divide. RAS is a protein that is very much like the G-protein that I described before in the beta-adrenergic receptor. It’s of similar size and it also binds to guanine nucleotides. The guanine nucleotide that it binds to here is GDP. And when it gets activated, which is what’s happening in this process, the GDP is replaced by GTP and RAS is now...

    About the Lecture

    The lecture Epidermal Growth Factor Receptor (EGFR) by Kevin Ahern, PhD is from the course Hormones and Signal Transduction. It contains the following chapters:

    • Epidermal Growth Factor Receptor (EGFR)
    • RAS

    Included Quiz Questions

    1. It can stimulate growth in the absence of hormone.
    2. It requires EGF to dimerize.
    3. It is inactive when it dimerizes.
    4. All of the answers are true.
    5. None of the answers are true.
    1. All of the answers are true.
    2. ...recognizes phosphotyrosines.
    3. ...stimulates cell division when it forms.
    4. ...favors release of GDP from RAS.
    5. None of the answers are true.
    1. It is focused on stimulating transcription.
    2. It requires RAS to be a dimer to function.
    3. It gets a phosphate put onto its GDP to make GTP.
    4. All of the answers are true.
    5. None of the answers are true.
    1. All of the answers are true.
    2. They include RAS.
    3. They include a part of G-proteins.
    4. They remove phosphates from other molecules/proteins.
    5. None of the answers are true.

    Author of lecture Epidermal Growth Factor Receptor (EGFR)

     Kevin Ahern, PhD

    Kevin Ahern, PhD


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