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So most endocrine glands are going to operate well into our old age; however, we find that
our growth hormone levels begin to decline with age and accounts for things like muscular
atrophy as we get older. The thyroid hormones also decline with age and contribute to our
lowering of our basal metabolic rate or how our metabolism slows as we age. The parathyroid
hormone levels are going to remain fairly constant with age. However, in older women
because of the lack of estrogen, they can become more vulnerable to bone demineralization
effects of the parathyroid hormone. Glucose tolerance can also deteriorate with age and is
usually associated with insulin and glucagon. Also as we age, the ovaries undergo significant
changes and become unresponsive to the gonadotropins. This problem is associated with an
estrogen deficiency. In males, testosterone also begins to diminish with age but the effects
are usually not seen until very old age.