00:01
Empyema also
develops independent of pneumonia.
00:05
So for example, there are patients who present with just
pleural infection with primary community-acquired
pleural infection where the pleura has been
affected directly. The root of their infection
is not clear but there is no associated pneumonia.
And of course, hospital acquired infection
can also cause empyema, and that might be
due to pleural procedures or surgery where
you get direct introduction of the bacteria
during the procedure of the surgery, or it
might be a consequence of hospital-acquired
pneumonia as an analogous situation to what
happens in the para pneumonic effusions and
community-acquired pneumonia. And all these
situations can lead to somebody with frank
pus in the pleural space and empyema.
00:45
So, how do you identify somebody who may have
pleural infection? It’s very simple. If
you have evidence infection, a pyrexia, a
raised C-reactive protein and evidence of
the pleural effusion, you need to think that
the patient may have a bacterial infection
of the pleural space. The classic blood results
you get in somebody who’s had an empyema
for two or three weeks or a pleural infection
for two or three weeks, there’s a raised
C-reactive protein, a low albumin, low haemoglobin,
and a raised platelet count. These are sort
of inflammatory effects of the ongoing infection
in the pleural space.
01:26
If you have somebody who you suspect may have
pleural infection, you must do a pleural tap,
the main differential diagnoses for simple
parapneumonic effusions and tuberculosis for
this situation. So somebody presenting with
what you think is an infection of the pleural
space tends out to have pneumonia of a parapneumonic
effusion or it could be that they have tuberculosis
of the pleural space. Those are the main differential
diagnoses. But the important thing here is
that if somebody presents with evidence from
infection and the pleural infusion, you must
do a pleural tap. When you do the pleural
tap, the findings
that might suggest pleural infection is it’s
an exudate with raised albumin levels but with a
low glucose. It’s confirmed as being an
infected pleural fluid if either the culture
or the microscopy identifies the infected
bacteria. Unfortunately, there’s a relatively
insensitive test or if the pH is less than
7, or if it’s visibly turbid, looks opaque
white due to the high neutrophil count
The other thing that is very suggestive of
pleural infection is the presence of loculations.
These are the adhesions between the visceral
and the parietal pleura which cause divisions
in the pleural space which are not normally there.
Now, loculations of the pleural spaces are
not easily picked up by chest X-ray. The shape
of loculated fluid can be seen by the chest
X-ray, as seen in this one, but the actual
loculations you cannot see. Ultrasound, in
contrast, is very sensitive. It can very often
identify loculations well before you can see
a loculated fluid on a chest-X-ray. And the
other method of identifying loculated fluid
is a CT scan which can easily describe patients
with different patches of fluid due to loculations
around the pleural space. So, how do you treat
somebody with bacterial
infection of the pleural space? Well, you
do the diagnosis pleural tap, ultrasound,
CT scan, and then the next thing to do is
drain the infective fluid. We do that for
two reasons. One is that if you drain your
infective fluid, it’s like draining an abscess.
03:31
It makes control of the infection much easier.
You’re reducing the bacterial load. The
other is that the long-term consequence of
empyema and pleural infection is that you
get pleural thickening. And the less pleural
fluid there is left in the patient, the less
pleural thickening you’ll end up with. So, you do
drains that will be inserted, usually
under ultrasound guidance, but the main problem
with all of these loculations and the thick
fluid you’re getting in empyema makes drainage
of the fluid much more complicated because
the loculations will prevent drainage occur
from different locules around the pleural
space. For that reason, some people have used
intrapleural fibrinolytics in the past, and
those may be beneficial in increasing the drainage
of pleural fluid, although the controlled
trial data are not clear-cut or present.
The ultimate way of removing fluid which is
difficult to drain if somebody has a complex
pleural infection is by surgery. And in fact,
quite a lot of patients with empyema, with
baterial infection of the pleural space, maybe
a third of them will require some from a surgical
intervention to clear out that pleural space
properly. Bacterial infection of the
pleural space is
complicated because it means the patient requires
prolonged treatment of antibiotics. And the
antibiotics they require depends on the source
of the bacterial infection. So for example,
community acquired empyema, either due to
primary empyema or due to associated
community-acquired pneumonia. There are normally
streptococci and anaerobes that are the main bacteria
causing infection. Other patient can be treated
with coamoxiclav or clindamycin. If it’s
a hospital-acquired empyema, then more difficult
organisms such as Staphylococcus aureus including
MRSA and the resistant grand negative organism
such as Pseudomonas become a problem, and
they will require much more complex regimens
of antibiotics to control the infection.
05:22
Overall, pleural infection actually is not
a good disease to have. If you’re over 65
years of age, there’s a significant mortality
about 30% over the hospital stay. And the
hospital stay itself, if somebody comes in
the hospital with pneumonia, the normal duration
of that hospital stay is only a few days.
If they have pleural infection, it increases
to 17 days at least. As I already mentioned,
the antibiotic treatment is about four to
six weeks length in duration. The patient
will need pleural drains and a significant
number will require pleural surgery. So, developing
a pleural infection is a major,
major problem for the morbidity and mortality.