00:02
The other big diagnostic tool for ectopic
pregnancy is checking a serum HCG.
00:07
HCG is a hormone secreted
from the growing fetus.
00:12
And in the first 6-7 weeks of pregnancy the
beta HCG will double every 1.8 to 3 days.
00:19
So you can follow serial levels.
00:21
In the Emergency Department on that first visit,
you’re just gonna be able to get one discreet level
but there's a following of serial level, so
following levels for patients if they're discharged
or even if they have an ectopic pregnancy
that’s treated can be very helpful.
00:36
Because you want to see in a normal pregnancy,
those levels will double that every 1.8 to 3 days,
but in an abnormal pregnancy like an ectopic
pregnancy, those levels will not be doubling,
those levels will be going down.
00:52
So what does the HCG level tell you about
what you should see on your ultrasound?
So for normal intrauterine pregnancy, that’s a
pregnancy that’s implanted in the right place
that’s developing normally.
01:16
On a transvaginal ultrasound, you would
start to see stuff at a levels 1000-2000.
01:23
However, ectopic pregnancy has been
diagnosed at very low levels of HCG.
01:28
So what is this telling us is that we
don’t wanna go ahead and use our HCG levels
to talk us out of getting an ultrasound
or to tell us not to get an ultrasound
or for us to call our radiologist to say, "Well,
the HCG is 500, we’re not gonna get an ultrasound."
Ectopic pregnancy can be
diagnosed at very low levels.
01:48
It will help you interpret what you see the HCG.
01:51
But it won’t necessarily or should
never talk you out of getting a test.
01:55
I personally have diagnosed ectopic pregnancy
in a patient who had an HCG level of 250.
02:01
And I know people who have anecdotally had ectopic
pregnancies diagnosed with levels in that range.
02:08
So go ahead and check the
level, but don’t let it use you.
02:12
Don’t use it to talk you
out of getting the test.
02:16
What other blood work should
you get for your patients?
So you’re working on getting an
ultrasound, you’ve checked the HCG level.
02:22
You want to check the CBC.
02:24
Now even in ruptured ectopic pregnancy,
the hemoglobin may be normal.
02:28
And the reason for that is that it takes our
body sometimes a little bit to equilibrate,
and have that hemoglobin have her reflect and have it
dropped and have them be a reflection of the bleeding.
02:39
The other very important lab
to send is the type and screen.
02:42
And the reason that we send the type and screen
for all patients with vaginal bleeding in pregnancy
is to prevent the blood type from the mother
reacting with the blood type from the baby.
02:53
So if someone has a negative blood type,
so if they’re A negative, O negative,
that patient will need RhoGam.
02:59
And the reason we give RhoGam is we use
it to prevent future Rh incompatibility.
03:05
Because the issue would be, if
the baby had positive blood,
so the fetus that’s developing has positive
blood and the mother has negative blood
and those blood types get
exposed to one another.
03:17
They can react to one another.
03:19
And then the mom can make antibodies to that
blood type and if she were to get pregnant again,
then that will cause issues
with future pregnancy.
03:29
You know, if you’re concerned that the patient
will need surgery or a blood transfusion,
a type and cross maybe beneficial.
03:35
So type and screen tells you the blood type and whether
the patient has a negative or a positive blood type.
03:40
Type and cross is when you start
getting blood ready for the patient.
03:44
So that’s when you start preparing the blood.
03:48
Now the ultrasound is your test of choice and
your imaging modality of choice to diagnose it.
03:53
Ultrasound will show an ectopic pregnancy either in
the fallopian tube or within the corner of the uterus.
04:00
And basically, it will look like a gestational
sac or a very early developing fetus in that area.
04:06
Sometimes, depending on how far the pregnancy is
advanced, you’ll see fetal heart tones as well.
04:14
You know, this ultrasound is actually an
example of an indeterminant ultrasound.
04:18
So what happens with some people who
present vaginal bleeding in early pregnancy
is you’ll get the ultrasound and the
ultrasound will show an empty uterus.
04:28
It won’t show anything in the uterus.
04:29
It won’t show a normal intrauterine pregnancy,
but it also doesn’t show an ectopic pregnancy.
04:35
So we want to be thinking about what
we’re gonna do for these patients
and how we're going to advise them because
we don’t have a clear diagnosis right now.
04:43
So if your ultrasound is indeterminant, so
what we mean by that is you do the ultrasound
and you don’t see an ectopic pregnancy
and you don’t see something in the uterus.
04:52
Ectopic pregnancy is more likely if
the HCG levels are less than 1000.
04:57
You know, if your HCG levels are above 1000 or
above that discriminatory zone at 1000-2000 range,
you might be starting to wonder
where the pregnancy in fact is.
05:08
In those situations, you may need to
consult ObGyn to help them sort out
what the next best steps are for that patient.
05:16
Now, if your patient is unstable or there’s
evidence of irritation to the peritoneal cavity,
so their belly is tense and rigid, they have
a lot of guarding or rebound tenderness,
the next step here should be a point of care
ultrasound FAST in the ED to look for free fluid.
05:35
So what that is, the FAST scan is
discussed in other lectures on trauma.
05:39
But what it looks for is it looks
for free fluid in the abdomen.
05:43
So if someone has a ruptured ectopic pregnancy,
they're going to have blood in their abdomen.
05:49
So that point of care ultrasound FAST
can do a good job at looking and seeing
if there's any blood in the abdominal cavity.
05:57
Now again, if you see blood in the abdominal cavity
and that patient has a positive pregnancy test
and they’re unstable, you get on the phone
and you get your patient to the operating room
as quickly as possible.
06:09
You know, if the work up is unrevealing, so let’s
say, you’re not really sure what’s going on.
06:13
The ultrasound isn’t very revealing, the
patient's lab values aren’t super revealing,
but your patient is unstable, so they
still are hypotensive, they’re tachycardic.
06:23
That patient may benefit from
a diagnostic laparoscopy.
06:27
So what basically happens there is the OBGyn team
goes in to the abdomen and they take a look.
06:33
And they see if there’s any
evidence of bleeding or any concerns
that weren’t seen necessarily
on the other imaging studies.
06:42
Laparoscopy is the surgery that
takes place using the cameras.
06:46
So the patient won’t have a big open scar or anything
along those lines in case something isn’t found.
06:52
Beware of the heterotopic pregnancy.
06:55
So heterotopic pregnancy, what that means
is it means that you have one pregnancy
that’s implanted in the uterus, so one
intrauterine pregnancy and one ectopic pregnancy.
07:07
So the patient essentially has
two pregnancies in the body.
07:10
One being normal and one being
implanted in an abnormal place.
07:14
You know, this is relatively
rare in spontaneous conceptions.
07:18
I actually have taken care of one individual in my
life that's had this via a spontaneous conception.
07:24
But there's increased incidents of this in
patients who are undergoing in-vitro fertilization.
07:31
Always make sure that
you’re thinking about this.
07:32
This is another one of those reasons that I
go ahead and I get formal ultrasounds almost
all the time in these patients, because
even though I see something in the uterus,
that doesn’t necessarily always rule out the fact
that there could also be an ectopic pregnancy.
07:48
So go ahead, think about this.
07:50
You may or may not ever see it.
07:52
It’s a relatively rare diagnosis.
07:54
But it’s something that can be very
life threatening to the patient.