00:01
Hi.
00:02
Welcome to our video on diabetic medications.
00:06
Let's get started with a question.
00:08
So, after we read the question, I'm
going to want you to pause the video
and write your answer before you look
at the rest of the presentation.
00:15
Ready?
Okay, which type of diabetic
patient cannot receive
most of the oral anti-diabetic
medications, and why?
The answer is type 1 diabetic patients.
00:36
They don't benefit from most of
the anti-diabetic medications
because the beta cells of their
pancreas have been destroyed.
00:44
The mechanism of action of most of
these oral anti-diabetic medications
is to stimulate insulin release
from the pancreas.
00:52
So, the damaged pancreas of a type 1 patient is
not able to accommodate these oral medications.
00:59
Now, when we're addressing
anti-diabetic medications,
we're looking at drugs that are against diabetes,
so they're going to help us lower blood sugar.
01:07
There's 2 major groups.
01:10
Oral drugs, which I love the graphic that they put
here for you, and non-insulin injectable drugs.
01:17
These are drugs that we use to treat
diabetes, but they can't be swallowed.
01:21
They have to be injected and they're not insulin.
01:24
Most of the drugs that we'll discuss
fall into the oral category,
but there's a couple that we'll talk
about in the injectable category.
01:31
Now, there are 7 families of oral anti-diabetic
medications that we're going to go over.
01:36
So these drugs are taken by mouth.
01:39
There's the biguanides, the second generation
sulfonylureas, the meglitinides --
we call those the glinides,
the thiazolidinediones --
we just call them glitazones, the
alpha-glucosidase inhibitors,
the DPP-4 inhibitors, and the dopamine agonist.
01:57
So, now here's a study tip.
02:00
Mark this slide in your
notes in your presentation.
02:03
Because it has 7 of the major classes
and categories of oral medications
that we use for type 2 diabetics, I
want you to use this as a reference.
02:11
Go back to this slide to quiz yourself.
02:14
That's the most effective
way to check your learning.
02:16
Just randomly pick a number, put your finger on it,
or have somebody in your family
pick a number between 1 and 7,
and then go down the lists of things that
you know about each drug as they call it.
02:27
So, ask your roommate to pick a number.
02:30
If they pick number 3, then share
what you know about the glinides,
why we use them, and what some
of the adverse effects are.
02:37
The more you quiz yourself over and over,
that spaced repetition will help you
recall and retain that information.
02:45
Now, there's one more group.
02:46
They're the sodium-glucose co-transporter 2s,
which is why we call them the SGLT-2 inhibitors.
02:53
This is another group of oral
anti-diabetic medications,
but this is what's really cool about this.
02:59
We can use it with type 2 diabetics,
but it also may be helpful for type 1.
03:05
This is news.
03:07
They're doing clinical studies now, but it's
really a cool development for type 1 diabetics.
03:12
Now, it does not replace insulin,
but it may help them be more effective
with their insulin, so stayed tuned.
03:19
We'll see what the research shows, but this
1 group, sodium-glucose co-transporter 2s
might have some really incredible clinical
applications for type 1 diabetics.
03:30
And it is the only one of the
oral medications that right now,
looking promising to deal with type 1 diabetics.