00:02
Let's go to another case.
00:04
Now, this is
a 69-year-old man
with a past medical history
of CAD and dyslipidemia
who presents with a slowly
progressive eruption of bumps
on his left knee
over the past year.
00:18
He's tried over the counter
anti-fungal creams
and an old topical
corticosteroid cream
but it just won't
go away.
00:24
He also reports some weight loss
of about 10 pounds
over the past six months.
00:29
Now, the lesions that are on
his knee are pruritic.
00:32
Over the next few months,
the lesions progressed
to areas of confluence,
some of which are ulcerating.
00:38
When you do the skin exam,
you see innumerable
pink papules and plaques of
varying size and shape
distributed on the
lower torso and the legs.
00:46
There's minimal scale,
and there's no pustules.
00:49
What do you think the diagnosis
could be in this case?
This is a tricky one.
00:55
This is mycosis fungoides
(cutaneous T cell lymphoma).
00:59
You wouldn't necessarily
come to that conclusion
just from the history
and physical alone.
01:04
But it's one of those conditions
that you have to think of it
or you'll never think of it,
get it?
Talking about mycosis fungoides
a little bit more
again, cutaneous T cell lymphoma
this is an idiopathic,
slowly progressive skin cancer
and essentially, it represents
a type of non-Hodgkins lymphoma.
01:23
The thing about
mycosis fungoides is that
it can present almost
any way that it wants to.
01:28
You're going to have persistent
and/or very slowly
progressive skin lesions
of varying size and shape.
01:33
You could have
localized patches.
01:35
You could have
widespread plaques
which appear to be
what's shown in this picture.
01:40
You can have tumors that continue
to enlarge and are exophytic
or you could have
generalized erythroderma.
01:45
Really, any different way it wants to present,
it can present.
01:49
Importantly, this can be
a fairly aggressive tumor
insofar as they can invade lymph nodes
and visceral organs as well.
01:56
It's just one of those things
that you have to have
on your differential diagnosis
even if it is fairly infrequent.
02:02
It's something you just have to keep
in the back of your mind.