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Corticopapillary Osmotic Gradient

by Thad Wilson, PhD
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    Now, we’re going to go through a couple of pretty difficult topics, and we’re going to spend a little bit more time trying to unpack them so you can understand them better. These are the corticopapillary osmotic gradient in the countercurrent multiplier system. To remind you of where we’re talking about in terms of the corticopapillary medullary gradient, as well as the countercurrent multiplier system, this is the loop of Henle. In the loop of Henle, we have a thin descending limb, we have the hairpin loop, the thin ascending limb, and the thick ascending limb. Notice histologically, these are very different cell types and you notice this because of the thickness of those cells. In terms of the thin limbs, they are very narrow in terms of their width, and that is because they don’t do much transport. This is a passive process that they’ll be involved with. They will either be permeable to a solute, or permeable to water, but not both. When we go to the thick ascending limb, you see there’s a number of mitochondria and their nuclei, and you can see all of the different transporters that might be expressed there. There will be an active process, meaning that you need to require energy for that transport process to work. What is the gradient? We’ve reviewed this earlier, and this involves both an anatomical and osmotic point of view. You can see from the cortex all the way to the medullary regions – there is a gradient of osmolality. It starts up near 300, which is an iso-osmotic type of condition, all the way down to about 1,200, which is hyper-osmotic. Having this gradient present, allows for the various transport processes in the loop of Henle. How this is set up? Now, we’re going to...

    About the Lecture

    The lecture Corticopapillary Osmotic Gradient by Thad Wilson, PhD is from the course Renal Physiology.


    Included Quiz Questions

    1. Sodium-chloride-potassium cotransporter
    2. Sodium-chloride exchanger
    3. Epithelial sodium channel
    4. Sodium-potassium ATPase
    1. Vasa recta vessels
    2. Peritubular capillaries
    3. Glomerular capillaries
    4. Medullary capillaries
    1. 750
    2. 300
    3. 450
    4. 600
    5. 500
    1. NCCK transporter
    2. Sodium-Potassium ATPase
    3. ROMK
    4. Chloride Channels
    5. Potassium Channels
    1. Potassium
    2. Sodium
    3. Chloride
    4. Calcium
    5. Magnesium
    1. Basolateral side has negative charge while apical side is positive charged
    2. Trans-electrical gradient is about 7 millivolt
    3. Ions move past due to voltage difference
    4. Calcium and Magnesium are reabsorbed para-cellularly
    5. Water can't travel para-cellularly

    Author of lecture Corticopapillary Osmotic Gradient

     Thad Wilson, PhD

    Thad Wilson, PhD


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