00:01
Okay.
00:02
Coronary vasculature.
00:05
So we've already talked about
kind of the way that
the vessels are laid out
and how they get
wrapped around the heart
and perfuse different
parts of the heart,
we're going to just briefly
review some of this.
00:16
Important point is that myocardial
perfusion occurs during diastole.
00:21
As the heart is relaxing,
when the heart is
squeezing blood goes,
whooshing by the
coronary artery,
take off the -- of
the coronary arteries.
00:30
You're not getting any
perfusion during systole.
00:33
It's only when the heart
relaxes, the valve closes,
and we get retrograde flow
into those coronary arteries
that we fill the heart.
00:41
So why do we care?
Well, normally,
during a normal heart cycle,
when your systolic squeeze
takes maybe a third of a second.
00:53
And if you're beating
at 60 beats per minute,
that means then you have two
thirds of a second during diastole.
01:00
Now, let's double your
heart rate to 120.
01:04
Now, you still have,
it still takes that same
third of a second to squeeze.
01:10
But now you have much less
time, half the time,
to fill during diastole.
01:16
So you can increase
heart rates so much,
that the heart no longer gets
blood into the coronary arteries,
and it can fail
on that basis.
01:24
Ah, important point.
01:27
So this is just looking
at when the vessels fill,
and you can see that it
happens when the aorta
is going through diastole.
01:36
So when the aortic
valve closes,
that's when flow goes
out the coronary vessels.
01:43
Okay, and finally to
the conduction system.
01:45
And let's work our way down
the basic structural elements
of the conduction system.
01:50
So the pacer,
the main pacer of the heart
is the sinoatrial node.
01:55
It sits at the junction of the right atrial
appendage and the superior vena cava.
01:59
So you can see that
indicated there on the right.
02:02
It runs the heart,
because it has the quickest release,
the quickest loss of
potential and then firing
of any other cell
type within the heart.
02:14
So in general,
that's going to be
where we have the regulation
of how quickly the heartbeats.
02:20
There's clearly
going to be hormonal,
and neural inputs
that also regulate
how the sinoatrial node fires
and how rapidly it fires.
02:32
Okay, we then once the
sinoatrial node fires,
we have to entrain
the rest of the heart,
we actually want the right
atrium, the left atrium,
to more or less
squeeze in tandem.
02:44
So we have a
Bachmann's bundle
that goes from the
sinoatrial node
and carries the signal over
to the left atrium and says,
Dude, time for you
to squeeze as well.
02:53
So that coordinates the
atrial contractions.
02:56
There are some then
ill-defined fibres
that are responsible for
getting from the sinoatrial node
to the atrioventricular node,
which sits pretty much near the
fibrous septum between the atria.
03:08
That atrioventricular
node holds
the signal for
just a little bit.
03:15
Why does it do that?
It does that so the
atrium can squeeze
and fill the ventricle one
last little bit about 15%
of ventricular filling
happens with that atrial kick.
03:26
So the AV node pauses for ever
so short a period of time,
allowing the
atrium to contract,
fill the extra 15%,
into the ventricle,
and then it sends the signal
down to the rest
of the heart,
down to the apex of the heart
through other fibers that
we're going to talk about now.
03:43
So there are there's
the bundle of His,
which is indicated in green,
and then there are the right
and left bundle branches
indicated as R and L,
that get us quickly
down to the apex.
03:54
All this connection system
is modified cardiac muscle.
03:58
It's not nerve,
it's modified cardiac muscle
that is very quick
and very efficient
at transducing a signal
down to the apex.
04:07
And then we get into
the Purkinje fibres.
04:10
And this is the
final kind of stage
before we cause the initial
depolarization of a cardiac myocyte.
04:18
Once any individual cardiac
myocyte depolarizes.
04:21
It has a calcium
transient increase
that calcium goes between
through gap junctions
into the next cell.
04:28
It spikes,
its contraction sends
calcium into the next cell,
in the next cell
in the next cell,
and we have this
coordinated wave
from the apex of the heart
squeezing blood up and out.
04:38
Beautiful,
beautiful!
And with that
we are concluded
and I hope you have enjoyed thinking
about how the heart is put together.