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Clinical Correlations: Huntington's Disease

by Craig Canby, PhD
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    About the Lecture

    The lecture Clinical Correlations: Huntington's Disease by Craig Canby, PhD is from the course Basal Ganglia.


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    1. Loss of GABAergic striatal neurons in the direct pathway
    2. Disinhibition of thalamus
    3. Overstimulation of cortex
    4. Loss of glutaminergic neurons in Nigrostriatal pathway
    5. Loss of excitatory influence on Globus pllidus internus
    1. Personality changes are rarely found.
    2. Ventriculomegaly is noted on imaging studies.
    3. Exhibits phenomenon of anticipation.
    4. It has autosomal dominant pattern of inheritance.
    5. CGA trinucleotide is repeated excessively.
    1. Loss of control over motor programs
    2. Difficulty initiating movements
    3. Disinhibition of Subthalamic nucleus
    4. Inhibition of thalamus
    5. Inhibition of motor cortex

    Author of lecture Clinical Correlations: Huntington's Disease

     Craig Canby, PhD

    Craig Canby, PhD


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