by Georgina Cornwall, PhD

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    Let’s go on to look at a condition of translocation. When we translocate between two chromosomes, there’s going to be some issues of how those chromosomes line up during cell division, specifically in the formation of the gametes on what gametes could be formed by those. In order for chromosomes to pair as homologs, they actually have to form this quadrivalent formation. That can form either balanced or unbalanced gametes. When the gametes are unbalanced, we’re going to see that the gametes end up producing some chromosomal abnormalities that could have features. Now, we moved on from cri-du-chat, totally different situation here with translocations from one chromosome to another. Multiple disorders could end up from these translocations. So, the first situation here is if they form the quadrivalent, they can only form it really in one way. If those chromosomes split on the horizontal axis, then we end up with unbalanced gametes. Unbalanced gametes, again you’re going to have some repercussions that would show up in the conceptus that results. If they split on the vertical axis, those homologs that are arranged in quadrivalent formation split on the vertical axis, we also would have unbalanced gametes developed from that. Now, there’s one condition in which we could end up with the translocation in formation of balanced gametes. So, we form the quadrivalent but now between the divisions, we see that the two pieces go on the diagonal. So those two pieces will end up in one gamete. The other two pieces will end up in another gamete. Thus, we form actually one normal and one balanced gamete. So, each of those situations have all the right amount of genetic information. So, we’re in that just right zone. But with the balanced situation, we could end up with a little bit...

    About the Lecture

    The lecture Translocation by Georgina Cornwall, PhD is from the course Chromosomal Disorders.

    Included Quiz Questions

    1. Quadrivalent formation
    2. Bivalent formation
    3. Ambivalent formation
    4. Trivalent formation
    5. Monovalent formation
    1. Alternate 2:2 segregation
    2. Adjacent-1 (horizontal) segregation
    3. Adjacent-2 (vertical) segregation
    4. 3:1 segregation
    5. 4:0 segregation
    1. Direct disruption of a gene at the site of translocation
    2. Haploinsufficiency in F1 generation
    3. Overexpression in F1 generation
    4. Epigenetic disruption of a gene at the site of translocation
    5. Aneuploidy in F1 generation

    Author of lecture Translocation

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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