00:01
Let's wrap up this look at statins.
00:03
Cholesterol is not a bad thing.
00:05
It is in every membrane of our cells.
00:08
We think LDL is the biggest contributor
to atherosclerosis.
00:12
So, lifestyle,
diet, and exercise can help
significantly impact
lowering our LDL levels and
raising our HDL levels.
00:22
Statins are the most effective
drug for lowering blood
LDL and cholesterol levels if diet
and lifestyle weren't enough.
00:29
Now, statins increase the number of LDL
receptors in the liver, remember?
That's a good thing
because if I have more
receptors in the liver,
I get more LDL into the liver and
out of the bloodstream.
00:41
The target we're looking for is an LDL < 100,
or if you have high risk, < 70.
00:48
Most of the statins should
be given at night
for the most effective treatment
for lowering LDL.
00:54
And remember, there are 2
rare adverse effects.
00:57
One is hepatotoxicity –
remember, damage to your liver -- and myopathy.
01:02
Now, you'll see a new word
there, rhabdomyolysis.
01:06
That is just a form of severe muscle
damage. It's so bad
that it ends up throwing your
patient into renal failure.
01:14
So myopathy is muscle damage.
01:16
Rhabdomyolysis is such a severe
muscle damage that it ends up
causing renal failure.
01:22
So, you want to monitor both
the liver function tests
and creatinine kinase levels.
01:28
Thank you for watching our video today.