00:01
So let's use this case to understand
the cerebellar nuclei.
00:05
What are the nuclei?
What do they do?
And how are they involved
in cerebellar function?
Well, there's four nuclei.
00:12
The first is involved
in coordinating in the output
of the lateral hemispheres
and this is the dentate nuclei.
00:20
This second two are the
emboliform and globose nuclei.
00:23
And those are important
for modulating
vermis and paravermis
circuitry and function.
00:29
And then the last is
the fastigial nucleus,
which is involved
in verbal outputs.
00:34
As we recall,
the flocculonodular lobe
sends its output directly
to the midbrain.
00:41
We can remember these
four cerebellar deep nuclei
with a mnemonic,
Don't Eat Greasy Food,
or Dentate, Emboliform,
Globose, and Fastigial.
00:53
If we look at where those are
located in the cerebellum,
we see here the dentate nuclei
are the largest
and most abundant
deep gray matter nuclei
in the cerebellum,
located laterally
similar to the hemispheres.
01:04
The emboliform nuclei are located
more medially to the dentate nuclei.
01:10
Here we can see the globose nuclei
adjacent to the emboliform.
01:14
And finally, the fastigial nuclei
located more superiorly.
01:20
What about their function?
What are each of these nuclei doing?
The dentate nucleus is the output
for the frontal cortex
and for the parietal cortex.
01:28
It's involved in that
cerebro-cerebellar pathway.
01:32
The interposed nuclei:
the emboliform and globose nuclei
are involved in the
spinocerebellar tracks
in coordinating postural tone,
spinal inputs to
vermis coordination,
and then spinal outputs.
01:48
And then last
the fastigial nucleus is involved
in modulating the
spinocerebellar pathway
receiving sensory afferents, and
vestibular and reticular efferents.
02:01
Note:
The flocculonodular lobe
relays directly
with the vestibular nuclei.
02:06
This information is involved
in coordinating the
vestibulo-ocular reflex
and not process through
a specific cerebellar
deep gray matter nucleus.
02:15
This is important
when we're coordinating
eye and head movements.
It needs to be immediate.
02:20
And so the less relays, the more
reflexive those actions can be.
02:25
And at the end,
I've included a table.
02:27
This is an important reference
for understanding
what the cerebellum does,
and why that's important?
We walked through
the lobes of the cerebellum,
the tracks, and the
deep gray matter nuclei,
as well as some of the diseases
that affect each of those areas.
02:42
We talked about the
anatomy of the cerebellum.
02:45
The lateral, intermediate,
middle, inner,
and the diseases that can affect
each of those areas.
02:51
And this table is an important
reference for understanding
each of those aspects
of the cerebellum.
02:56
And clinically, when we would
think about those.