Cellular Senescence and Stem Cell Exhaustion

by Georgina Cornwall, PhD

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    Now, onto cellular senescence which is sort of a result of this whole idea too. We’ll categorize these different physiological traits as we summarize the lecture. But cellular senescence is definitely one where we’re challenging the checks and balances of our cells. Cellular senescence by definition is the stable arrest of the cell cycle associated with phenotypic changes. It’s a protective mechanism, right? Recall that it is intended to prevent propagation of damaged cells and trigger their clearance by the immune system. Cellular senescence is actually something that we need in order to have a healthy life and healthy cells. Now, cellular senescence acts in a couple of different ways. When we’re young, this is how it works. We see sporadic damage. You’re familiar with this mechanism. Cellular senescence comes along and prevents propagation of bad cells or cells that don’t have everything right in place, prevents their proliferation to produce tissues. However, if the cells are undamaged or things get fixed then we can produce the right tissues. Now, this acts to prevent cancer naturally because if we have DNA damage, we don’t want to proliferate those cells. So, this is a mechanism of checks and balances to prevent against cancer. It allows us to age more gracefully, let’s say because we’re not letting these damaged cells proliferate. So, if we take care of ourselves, perhaps we can have our cell lines live a little bit longer. When we consider cellular senescence in the aging cell, we actually see an increase in cellular senescence. Keep in mind that cellular senescence means stalling of the cell cycle, right? So things that affect cellular senescence are going to be increased damage, all the things that we’ve actually discussed already, increased damage in the cells, decreased rates of repair, and decreased clearance...

    About the Lecture

    The lecture Cellular Senescence and Stem Cell Exhaustion by Georgina Cornwall, PhD is from the course Aging. It contains the following chapters:

    • Cellular senescence
    • Stem cell exhaustion

    Included Quiz Questions

    1. Increased damage in cells
    2. Increased rates of repair in cells
    3. Increased clearance of damaged proteins in cells
    4. Increased cell renewal
    5. Increased tissue homeostasis
    1. Slowing of cell division
    2. Anti-aging
    3. Cancer
    4. Increased tissue function efficiency
    5. Decreased inflammation
    1. Increased myelodysplasia
    2. Increased intestinal nutrient absorption
    3. Increased bone density
    4. Increased muscle tone
    5. Increased cell renewal
    1. Loss of Proteostasis
    2. Mitochondrial dysfunction
    3. Stem cell exhaustion
    4. Genomic ultrastability
    5. Deregulated nutrient sensing
    1. Cellular Senescence
    2. Telomere attrition
    3. Epigenetic alterations
    4. Genomic instability
    5. Loss of proteostasis

    Author of lecture Cellular Senescence and Stem Cell Exhaustion

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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