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in the wrong direction during contraction
of the ventricle. Now let’s move on and
look at the structure of cardiac muscle.
Cardiac muscle is a specialized piece of tissue,
so important to the function of the
heart. You need to be aware of its difference
between skeletal muscle and smooth muscle. Well,
cardiac muscle does have some characteristic
features. Firstly, it has got a central nucleus,
similar to smooth muscle, but skeletal muscle,
you may recall, has got many, many peripheral
nuclei. Cardiac muscle has also got striations
just like skeletal muscle, but unlike smooth
muscle that doesn’t have striations.
00:51
And cardiac muscle has structures called intercalated
discs, which if you look at the diagram on
the left-hand side, it explains what these
intercalated discs actually are, and what
their functional role is. They are of two
sorts of junctional complex. One is called
the fascia adherens. That’s an adherent
junction. It holds muscle cells end to end
in our cardiac muscle cells, our small cells,
relative to skeletal muscle cells. But unlike
skeletal muscle cells that are arranged in
parallel and their contraction is dissipated
onto a tendon to bring about movement at
a joint, cardiac muscle cells aligned end
to end and joined very strongly to each other
via this adherent junctions. And the other
top of component in these intercalated
discs are gap junctions. These gap junctions
allow the transmission of ions and different
messengers from one cell to the next.
02:00
And in so doing, contraction could be initiated
at one part of the cardiac muscle and move
all the way along through other cardiac muscles
in a certain sequence. And that brings about
the sequential pumping of the myocardium. You
see here in the diagram, these junctional
complexes are between two separate cardiac
muscle cells and they tend to be a little
bit disjointed or irregularly arranged between
the two cardiac muscle cells. That increases
the surface area of this contact from one
muscle cell to another, and therefore, further
enhances a very strong bonding between these
cells. The gap junctions tend to be isolated
on their own as part of this junctional complex,
whereas, the adherent junctions are also in
certain locations. So, there’s no confusion
between the two, in terms of their structure,
and therefore, in terms of their function.
In the previous section I showed you or previous
slide and explained the histological features
of cardiac muscle, you are looking at cardiac
muscle sectioned longitudinally. Here, on
the right-hand side of the slide, you can
see two sections taken through cardiac muscle,
transversely sectioned. On the far right hand
section is a section taken through the myocardium
of the ventricle. And on the left hand side,
the section is being taken through the myocardium
of the atrium. And if you look very carefully
at those two sections, I hope you’ll notice,
generally, that the thickness of the cardiac
muscle fibres in the ventricle are bigger than
the thickness of the cardiac muscles in
the atrium. And that’s because, if you recall,
the atria are only pumping blood into the
left or right ventricle. The ventricles, on
the other hand, are pumping blood under pressure
into the lungs or into the systemic circulation
through the aorta. Therefore, the pump needed
has to be a lot stronger. So the cardiac muscle
fibres in the ventricle are going to be stronger,
larger, wider because they have to have that
stronger pumping action. So you can see subtle
differences in the size of cardiac muscles
when you compare the atria with the ventricle.
04:45
And just in summary, it just refers to the
strength of the pump you need to pump the
blood from those two chambers. Well, let’s
look at the conducting system of the heart.