00:00
Hi! Welcome to our video series.
00:03
In this one we're going
to look at the lab work
and diagnostic tests
for a patient with a
myocardial infarction.
00:09
So when you suspect a patient
could having be having acute
coronary syndrome.
00:14
We're going to talk
about the lab tests
take a venous blood sample.
00:17
And these lab tests will
help us diagnose, evaluate
and monitor these patients.
00:23
Now first we're going to talk
about cardiac bio markers.
00:26
But what I want you to
put a little star
buyers Troponin I or T,
so just mark that for now
what we're trying to
identify we're looking to see
if the heart has
suffered any damage.
00:37
Now in your graphic there we
have the picture of the heart.
00:40
We've got a little
black into area around
where the heart did not
receive enough oxygenated blood
and so we have dead tissue.
00:48
That's what the bio
markers will tell us.
00:49
Has there been any
damage to the tissue.
00:52
Troponin I and troponin
T are often used.
00:55
We also have high
sensitivity troponin.
00:58
We'll talk about those
in just a minute.
01:00
Creatine kinase and CK-MB
those guys are ones we used
to use troponin is going
to be more effective
and sometimes myoglobin is used.
01:10
So we've given you four tests.
01:12
But the one I want you to really
remember is the one troponin.
01:15
That's the most important
one for our discussion.
01:18
So troponin are the
most commonly ordered
and most specific
of the bio markers.
01:24
So the other ones
can be helpful,
but troponin is going
to be the most specific.
01:28
Now this is a group of proteins.
01:30
They're found in skeletal
and cardiac muscle
and they control can
muscle contraction.
01:35
So what are troponins?
They are group of proteins,
we find it in skeletal and cardiac muscle.
01:42
There are what help control
muscular contractions.
01:45
They usually very small amounts
are present in the blood
if there hasn't been any damage.
01:51
So if we look at the
troponin results,
we can indicate if there's been
an injury to muscle tissue.
01:56
So that's why troponin
is a cardiac bio marker.
02:00
Now have three types
that are present
in small amounts in your blood,
troponin C,
troponin T and troponin I.
02:09
So these are the proteins
they're going to be an
indication if they're
an elevated levels that the
heart has suffered damage.
02:16
So there's little
difference between skeletal
and cardiac muscle
with troponin C.
02:21
So that one isn't used to
diagnose acute coronary syndrome.
02:25
We're looking mostly at
troponin T and troponin I.
02:29
Now to prone in T and troponin
I are more specific for cardiac
and that's their used to
devaluate cardiac damage.
02:35
You'll probably particularly
see troponin I predominantly
but both of these will rise
within three to six hours.
02:42
They'll peak at 24 to 48 hours
and they'll go back to baseline
over five days to 14 days.
02:49
So this is your basic to
troponin I or troponin T.
02:52
This isn't the high sensitivity
that we're discussing.
02:55
So troponin I and troponin T
have to draw a series of tests
to rule out cardiac infarction
Troponins are drawn
more than once
and over a period
of several hours.
03:06
So expect that if a patient
comes in with chest pain,
they're being evaluated.
03:10
We're likely going to keep
them for a period of time
over several hours,
so the repeat lab
work can be drawn.
03:17
Now if the patient
has renal dysfunction,
if their kidneys are
kind of struggling
this might interfere with the
accuracy of the troponins.
03:25
Because their clearance
might be decreased.
03:27
So you just keep that in mind.
03:30
Now we've come to the high
sensitivity troponin test.
03:33
Now this was just approved
in America for use in 2017.
03:36
So it's been around
for a little bit
but a relatively
shorter period of time
than it was been used in Europe.
03:42
So we came to the
party a little late.
03:44
But now you'll see this often a
high sensitivity troponin test.
03:49
It's more sensitive.
03:50
Hence the name,
High sensitive troponin.
03:53
The positive results appear
sooner than previous versions.
03:56
Well,
that'll help us rule out an MI
or identify one earlier so
these are really helpful.
04:03
So if you see this you'll
see it as a troponin
maybe HS will indicate that
it's a high sensitivity test.
04:09
So HS High sensitivity troponin
may also be present in
stable angina or no symptoms.
04:17
Now this may indicate
an increased risk
of future heart attacks.
04:21
Okay, so that's a good heads up
so they can be positive
even in stable angina
but that doesn't mean the patient
is absolutely out of heart attack,
but it may indicate
there's an increased risk
of future heart attacks.
04:33
So that's a little bit about
high sensitivity troponin.
04:37
Creatine kinase - i want to be sure
that you understand
that the troponin lab is more accurate, or specific, to
cardiac muscle damage
and is a prefered test over a CK.
04:49
Now, let me explain why
myocardial cells are
damaged in a heart attack.
04:54
That's why we call it
myocardial infarction.
04:57
Now the cell membranes released
this enzyme into the plasma
within the first
30 to 60 minutes.
05:03
So That cardiac
muscle is damaged,
these enzymes are released
in the plasma within
30 to 60 minutes.
05:10
Now CK is a measure of
these enzymes or CPK.
05:15
Remember if patients had
any kind of trauma like
defibrillation CPR other cardiac
interventions like a CABG,
These will also be considered
injury to the heart
and you'll have these
enzymes released.
05:27
So someone who's had these
known events happen will
also have elevated
cardiac enzymes.
05:32
Now the indicate muscle damage,
but it's not specific
to cardiac muscle,
we're talking about the CK.
05:38
So we have to do the isoenzymes.
05:41
Now those are the other
two letters at the end.
05:43
CK-MM would be skeletal muscle,
CK-BB is found in the brain
but CK-MB is found
mostly in the heart.
05:53
Now I know I keep saying this
but remember troponin is going
to be a more specific test.
05:58
But just in case you
see these test run
we want you to understand
what they mean.
06:04
Now CK-MB runs means
we've ordered a CPK
with ISO enzymes and we're
looking at the MB result
if we're looking at
damage to the heart
because it's sensitive
and specific to
myocardial injury
damage to heart tissue.
06:19
It rises within 4 to 8 hours
peaks at about 18 to 24
and it should go back to
normal within three days,
If there's not
ongoing heart attacks.
06:29
Now CK-MB must be
greater than 5%
of the total CK,
in order for a definitive
diagnosis of MI.
06:38
So let's look at the
difference in those again CPK.
06:42
That's more global.
06:43
CK-MB is an isoenzyme.
06:46
That's most specific to cardiac.
06:49
You've got the times
that you see the changes
first starts to rise within
four to eight hours in the test,
peaks at 18 to 24
and should be back to
normal in three days.
06:59
Now myoglobin might also
be used with troponins,
but it's not often.
Used in the US.