00:01
Biopsy is very quick
presentation because it's...
00:06
at your level, you will know
exactly what I'm talking about.
00:10
You know what is a biopsy?
You know the indication,
you know the purpose.
00:17
So this is all very
straightforward theory.
00:20
But what will be honest,
the exam is the types of biopsy.
00:25
So FNAC, commonest things we
do are thyroid and breast.
00:31
Common things for FNAC.
00:34
Advantage and disadvantage: simple,
cheap, and minimally invasive.
00:39
The biggest disadvantages,
it doesn't really show anything.
00:42
It just says there is some cancer
cell or there is no cancer cell.
00:46
But if there is cancer cell,
you just don't know
what type of cancer,
you don't know whether the
DCIS or LCAS or Foley clot.
00:53
You don't know nothing.
00:54
So that is a simplest form
of investigation you do.
00:58
Classically they say,
you are the researcher or registrar
in the clinic and
the boss is away
and you have a patient with
an enlarged lymph node.
01:07
What investigation
can you do then?
The only thing
you can do is FNA,
because that's a simple thing to
stick a needle, take some cells out.
01:15
Okay, you just can't
leave the patient
will go home because
your boss is away.
01:18
You need to do something,
so you can refer the patient
to have an ultrasound
or do an FNA.
01:25
Some in us is a fairly
basic investigation.
01:29
Similarly, brush cytology,
very specific for cervical smear.
01:34
Again, risk and benefit
are very similar to FNAC
and higher risk of
false negatives.
01:40
So it is not a
good investigation.
01:41
There are more like screening.
01:44
As you go to core biopsy,
this is where you are getting
into the real meat of the issue.
01:50
You get, it allows for
architectural evaluation.
01:54
But clearly there is
risk of bleeding painful,
and it may alter morphology.
02:01
What is alter morphology mean?
In which condition would
you not do a core biopsy?
Classically.
02:08
Let's say you have a some tumor.
02:09
I'm talking about some tumor.
02:13
Will alter morphology
if you do a core biopsy?
Core biopsy is
putting a thing and
taking core out.
02:19
Melanoma.
02:21
Okay, because melanoma you need to get
the brush load depth too accurately.
02:25
You don't want to mess
about putting a core in,
pulling it out and then the
whole architecture is distorted.
02:31
Okay, so that's an absolute
contraindication for doing a core biopsy
or incision biopsy.
02:37
The only biopsy you're allowed to do
in a melanoma is an excisional biopsy.
02:42
Okay.
02:43
So core biopsy very,
very commonly do in clinic, breast.
02:48
Okay, so triple
assessment, your component,
one of the component
will be core biopsy.
02:55
Then you have your
endoscopic biopsy,
which you do to
avoid open surgery,
operator dependent,
risk of bleeding, perforation.
03:12
Apparently, a couple of days ago,
they had a patient with a colonoscopy.
03:16
Two days ago and patient
returned with splenic rupture.
03:24
Yes,
are the investigations done
injustice real apparently?
So anyway, so they took a biopsy
from the cecum for a cecal tumor
and two days after the splenic rupture
the patient had a perforated bowel
from the cecum.
03:41
Because if they were
pushing the scope
and (inaudible)
and hit the spleen.
03:54
And then, they went in took a biopsy from
the cecum and got a perforation from that.
03:59
So, I'm sure yeah.
04:04
Okay, so endoscopic biopsy
always has a risk of perforations
you need to consider that.
04:08
Then the Incisional
biopsy, excisional biopsy.
04:11
And now,
incision and excision biopsy,
usually for skin cancer
is very straightforward.
04:16
If you have a big
squamous cell carcinoma,
if you can cut out the whole
thing, go for it.
04:22
There's no point messing about
taking a small piece of tissue
and bringing the patient again.
04:27
You go for excisional biopsy,
just cut the whole thing out.
04:29
But if you can't, you want to have some
histology, you go for incisional biopsy.
04:34
That's it.
04:37
Okay, sorry. Anything so far?
I think it's all
logical, isn't it?
Frozen section.
04:43
When do you do frozen section?
What's indication?
Okay, would you do
frozen section thyroid?
This tutorial can do for a second,
what to say advantage of frozen section?
Frozen section, you can do for
something a basal cell carcinoma,
say on the face, say here.
05:09
You do something that called the
mohs, M-O-H-S.
05:12
We come across Mohs,
micrographic surgery.
05:15
Mohs, M-O-H-S,
is very specialized,
that is exactly frozen section.
05:21
Basically let's say,
imagine this is the eye,
this is the medial canthus
and you have BCC here.
05:35
Ideally, if you go for a 3 to
5 millimeter extension model,
you will end up
cutting out this much.
05:40
Got it?
So you can't do that because you
are taking on the medial canthus
lacrimal duct, etc.
05:45
So that's when you do something
called the mohs surgery.
05:49
Mohs, micrographic surgery,
where the patient is on table
the dermatologist or trail
them and cuts it out,
since it for frozen section,
waits for the report
and then if it says in six o'clock
position that is bit of tumor,
then they cut off that much,
then they say okay little bit of
here, they cut it out.
06:07
So essentially,
they cut on exactly what is required
rather than anything more
than what is required.
06:14
So in specific anatomic
areas is very useful
and that's for that
unit frozen section.
06:19
So the patient is under
general anesthetic
or local for the whole duration.
06:23
Sometimes you can
take four hours,
but the dermatologist probably
haven't got anything much anyway,
so for us is not bad.
06:30
So any dermatologist here? No.
06:32
I shouldn't say that.
06:33
Anyway, so that is Mohs and
that is your frozen section.
06:40
Okay anything on that?
That's all they will ask you.
06:43
Punch biopsy.
06:47
That is more like a core biopsy
or an incision,
so it's a combination of the two.
06:53
So we normally do,
in, say,
non-healing venous leg ulcers,
big ulcer,
the best way to take a biopsy.
07:08
It's a core biopsy
but there is no core
in a non tumors area.
07:14
When they use the
word core biopsy,
it means it's for tumor.
07:18
Yeah,
punch biopsy is same principle,
going in, taking it out
but it's not a tumor area.
07:28
Yes.
07:29
Yeah, punch biopsy.
07:30
We don't do punch biopsy
for breast cancer for exam.
07:33
You need to have a core biopsy
is much more sturdy resented.
07:36
You really go make sure.
07:38
It's painful, but yeah.
07:43
Okay, the last bit before the
break is local anesthetic.