Lectures

Biochemistry of Bilirubin

by Kevin Ahern, PhD
(1)

Questions about the lecture
My Notes
  • Required.
Save Cancel
    Learning Material 2
    • PDF
      Slides Bilirubin Biochemistry.pdf
    • PDF
      Download Lecture Overview
    Report mistake
    Transcript
    The topic of this set of lectures is that of the metabolism of bilirubin. Bilirubin of course is a breakdown product of heme and heme is one of the components of our red blood cells. Catabolism of heme actually begins in the spleen because it's in the spleen where the red blood cells are taken out of the blood supply. In this process, damaged blood cells are recognized by the spleen and these damaged blood cells have contents that have to be processed. One of the more important components of those blood cells, of course, is heme. Heme is shown in the structure in the lower left. Now the reduction of heme is the very first step in the process of converting heme into what will ultimately become bilirubin. The first step in the process involves the production of biliverdin as you can see here. And this reduction reaction uses electrons from NADPH. It also uses oxygen. And this oxygen is actually oxidizing a part of heme. So this is a complicated reduction oxidation that's actually happening to make biliverdin. Well the reaction is complicated, but the product is not very complicated. As you can see, biliverdin looks very much like heme does on the left with the exception of the top bond that has been broken where two oxygens have been substituted. Heme is converted in this reaction by the enzyme known as heme oxygenase that makes this overall process happen. And again, we see the involvement of molecular oxygen as we have seen in numerous other metabolic processes. There's the top bond that's been broken and there's the production of the two oxygen atoms that I described earlier. Now the increased activity of heme oxygenase is important because it's a signal to the body to start making more...

    About the Lecture

    The lecture Biochemistry of Bilirubin by Kevin Ahern, PhD is from the course Amino Acid Metabolism.


    Included Quiz Questions

    1. Heme arises when blood cells are damaged.
    2. It produces bilirubin, catalyzed by heme oxygenase.
    3. It occurs primarily in the blood.
    4. None of the answers are true.
    5. All of the answers are true.
    1. It produces bilirubin.
    2. It results in a less flexible molecule.
    3. All of the answers are true.
    4. None of the answers are true.
    1. It catalyzes the conversion of biliverdin to bilirubin.
    2. It produces reactive oxygen species.
    3. It recycles biliverdin to heme.
    4. None of the answers are true.
    5. All of the answers are true.

    Author of lecture Biochemistry of Bilirubin

     Kevin Ahern, PhD

    Kevin Ahern, PhD


    Customer reviews

    (1)
    5,0 of 5 stars
    5 Stars
    5
    4 Stars
    0
    3 Stars
    0
    2 Stars
    0
    1  Star
    0