So, we've covered a lot of territory in just describing
the basic cellular housekeeping functions,
the things that every cell has to do to be a cell.
And I think that's really important. Just like Koch said,
"Pathology begins at the cellular level."
So, understanding these pathways.
Although, it may seem at times like arcane biology,
it's really important for understanding a lot of human disease
and if you understand the concepts,
the rest of it just kind of falls out as they say, it's just details.
So, plasma membrane is important for interfacing with the outside world.
Okay, that's how we have the cell interact.
It's also once we create that barrier, that protection from the outside world,
that interphase, we have to move things across it,
so, we have to have transport
and we also have to have a way for the cells to communicate,
one with another or over a distance.
So, all the signaling molecules that we talked about.
There's cytoskeleton conveying motility and structure.
So, giving organization and architecture to the cells as well as allowing them to move.
Synthesis, so, we talked about the rough ER, the smooth ER,
the gogli apparatus as part of the synthetic machinery
for these constantly turning over organelles and proteins and lipids and everything else.
So, there's constant synthesis balanced with degradation
that's going on through the lysosomes,
the proteasomes, peroxisomes, autophagosomes.
Finally, there's energy generated through ATP in the mitochondria
but mitochondria also really, really, really important
for other things like apoptosis, cellular suicide.
And then, everything has to turnover.
Everything has to be regulated and there's the nucleus with the chromatin architecture
and the structure of the nucleus also being important in driving its normal function
as we saw with the Hutchinson-Gilford Progeria.
So, we covered a lot of territory.
We will revisit the concepts again many, many, many times
because this is where the pathology begins.
So, it's been great and we're gonna go on to the next topic.