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Direct and Indirect Basal Ganglia Pathway

by Craig Canby, PhD
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    Now within the multitude of connections that we saw in the previous slide, the connections can be divided into a direct pathway as well as an indirect pathway. Both of these pathways are going to ultimately influence the state of the cerebral cortex. The direct pathway is the simplest one in that there are fewer connections. So this takes a more direct circuit route to influence the cerebral cortex. Let’s take a look at the components of the direct pathway. First, this direct pathway is going to stimulate or excite the motor cortex. This is how it goes about doing so. Here we have the connection that exists between the striatum and the globus pallidus, so striatal pallidal. From the globus pallidus, we’ll have a connection here to the thalamus. Then from the thalamus, we can then excite the cerebral cortex. Then the cerebral cortex can communicate back with its circuitry to the striatum. Now, what I want you to do now is to think about math. The connections have been changed in color so that we have red and green. Red would be inhibitory influences, whereas green is an excitatory influence. We want to look at how this direct pathway excites the cerebral cortex, so we’re looking at this communication or circuit, the circuit here and the circuit here. We want to think about math here to think about the fact that the direct pathway excites the cerebral cortex. For each red arrow, you’re going to have a minus one. For this final green arrow, you'll have a plus one. Minus one times minus one is plus one. Plus one times plus one is a positive or an excitatory influence. There’s also an indirect pathway between the basal ganglia to the cerebral cortex. Activation of the indirect pathway has...

    About the Lecture

    The lecture Direct and Indirect Basal Ganglia Pathway by Craig Canby, PhD is from the course Basal Ganglia. It contains the following chapters:

    • Pathways – Direct
    • Pathways – Indirect
    • Pathways – Nigrostriatal

    Included Quiz Questions

    1. Globus pallidus internus has an inhibitory effect on Thalamus.
    2. Dopamine inhibits the direct pathway.
    3. Inhibition of Globus pallidus by striatum also inhibits thalamus.
    4. Striatum has excitatory effect on Globus pallidus internus.
    5. Direct pathway has an inhibitory effect on cerebral motor cortex.
    1. …Subthalamic nucleus
    2. …Substantia nigra
    3. …Putamen
    4. …Globus pallidus externus
    5. …Globus pallidus internus
    1. Dopamine stimulates direct pathway via D1 receptor and induces motion.
    2. Dopamine inhibits indirect pathway via D2 receptor and inhibits motion.
    3. Dopamine acts on both D1 and D2 receptor and excites both inhibitory and excitatory pathways.
    4. Dopamine inhibits the excitatory pathway.
    5. Dopamine excites the inhibitory pathway.

    Author of lecture Direct and Indirect Basal Ganglia Pathway

     Craig Canby, PhD

    Craig Canby, PhD


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