Autosomal Dominant Inheritance

by Georgina Cornwall, PhD

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    With that being said, now we move on to autosomal dominant inheritance. You can see here that it has a different expression pattern. If you carry the allele, the dominant allele, you are affected. That’s why it’s considered dominant. Here, you can have a carrier. We have the same cross, carrier mother, carrier father. In this case, they will have mostly affected children because anyone actually having the allele which is ¾ of the family will end up with that disorder. In that sense, these are much more prevalent disorders. Here are two types of matings that could lead to affected offspring. Keep in mind that anytime there is uppercase D, the individual is affected. In our first cross here where we have a heterozygous parent and a homozygous recessive parent, we will see that 50% of the individuals are affected, so we have a probability of 50% of offspring being affected. In this next cross, you think about this one if both parents are heterozygous as they were in the earlier figure. We have a ¾ possibility or 75% possibility that the offspring will be affected by this particular disorder. Now again, there are a number of different disorders but they all exhibit this very common Mendelian inheritance pattern. Dominant conditions in general have a higher incidence. Not because those alleles are necessarily more frequent, it’s because if you have the uppercase letter, the dominant allele, then you are going to express the disease. There are going to be more of the dominant alleles in the population. Otherwise, they wouldn’t be called the dominant allele, right? An example that we can look at here is polycystic kidney disease. In certain populations, we might see a higher frequency of the alleles. One in one thousand individuals in the United States...

    About the Lecture

    The lecture Autosomal Dominant Inheritance by Georgina Cornwall, PhD is from the course Single-Gene Disorders.

    Author of lecture Autosomal Dominant Inheritance

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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