00:00
Hi! Welcome to our video
series on the liver now.
00:04
We're talking about
hepatitis and liver disease.
00:07
In this one I'm going to give
you an example of a calculator
that we use as clinicians
to assess the
severity of cirrhosis.
00:15
Now clinical calculators are used
for all different types of systems.
00:20
These are just tools
and we use them to assess
the severity of the illness
in the risk of poor outcomes.
00:27
So these tools are used
to decide things like
which clinical interventions
would be best for the patient
help us determine
how sick they are
or term that you've
heard as far as acuity.
00:37
The higher the acuity,
the sicker the patient is
the more resources they need
and possibly even the more nurses
they need to care for them on a shift.
00:47
Now clinical calculators can
even use to make decisions
regarding transplant priorities.
00:52
Patients with livers that
are damaged or destroyed
are candidates for
a liver transplant.
00:59
The sicker the patient becomes
the more of a priority they
become on the transplant list.
01:05
Now I'm going to give you talk about
a couple examples of calculators,
but I'm going to walk you
through the CTP specifically.
01:12
Now when a liver is damaged,
It's decompensated cirrhosis
has gotten to the point
where they're now
in liver failure.
01:19
The patient is at a
high risk for death
or what we call mortality.
01:24
So that's why I clinical calculator
seems kind of a cop doesn't it,
a little bizarre,
but it's actually a very
helpful clinical tool.
01:33
We're not putting a value
on the patient's life.
01:36
We're trying to quantify
how sick they are.
01:39
Now there's a CTP score
and there's also a MELD.
01:44
Which is a model for
end-stage liver disease.
01:47
These are two examples of tools
that the health care team can use
for patients with liver damage.
01:52
Now, you may notice that you're
seeing the MELD more often,
but either way whether you're
seeing the CTP or the MELD
that's going a decision
made by the physician team
in the facility of which
one they prefer to use.
02:06
The sad news is that
cirrhosis is progressive
unless the patient can
take extreme measure,
recognizes the problem early on,
the disease is going to progress to a
point that becomes life-threatening.
02:19
On the left, I've got a picture
of healthy hepatocytes for you.
02:22
It's looks good,
everything's in order,
things can flow through that as
they were intended in the liver,
but look to the cirrhosis side,
look you can see the blow-up
picture that we have for you there,
look the cells are not in order.
02:36
You've got remnants
of dead cells.
02:38
It's fibrotic just
doesn't function as well.
02:41
So how do we go from
healthy to cirrhotic?
Well, as those liver
cells are destroyed
whatever was the original
cause of the patient cirrhosis
of the liver tries to
repair itself fight back,
but it doesn't build it back
in as efficient of a manner
when cells are rebuilt, they're never as
efficient as the original ones of the liver.
03:04
The damaged cells are fibrotic
have cirrhosis and scarring
and they've got these nodules
so it works but it's definitely not like
the original liver healthy hepatocytes.
03:18
So cirrhosis is progressive.
03:20
You don't go from healthy one
day to wildly cirrhotic the next,
it's a process.
03:27
So we have some
time to intervene
if we can work with the patient
during the time of initial diagnosis.