00:01
The next structure
we're going to talk about
in the hematologic
system is the spleen.
00:08
Now, here we go into the
abdomen so we can see the stomach,
giving rise to the first
part of the small intestine,
which is the duodenum
which is very closely associated
with the pancreas because it
receives the pancreatic duct here.
00:24
And just off to the left
somewhat behind the stomach
and hidden by it is a
little bit of the spleen.
00:31
Now, the spleen is quite different
from these other abdominal organs
that pretty much all have
something to do with digestion.
00:37
Of course,
the spleen isn't really
related to digestion,
it's hematologic.
00:42
But if we were to
fade out the stomach,
we could see the
spleen and its relationship
to these structures
much more clearly.
00:50
So again, here's the spleen.
00:52
And then we see that we
have the abdominal aorta,
and a branch of the
abdominal aorta that we
mentioned in the GI section
called the celiac trunk.
01:02
And one of the branches of the
celiac trunk is the splenic artery,
which runs along the
length of the pancreas
until it reaches the tail
of the pancreas that sits
right up against the
medial surface of the spleen.
01:17
And similarly,
the splenic vein is going to follow
that same course
going along the backside
of the pancreas until it
reaches the portal vein.
01:29
Here's a more medial view.
01:30
So we can see the
spleen a little bit better.
01:34
And again, like a lot of
organs that are otherwise solid
and just have one entry and
exit point for vessels, there's hilum.
01:43
And so the splenic hilum,
is on the medial surface,
basically facing the tail end
of the tail of the pancreas.
01:51
And again,
that's where we're going to have the
splenic artery entering,
the splenic vein exiting.
02:00
Again, we have the artery
and vein entering the hilum.
02:04
And it's going to branch into many
smaller and smaller blood vessels.
02:09
And all of these blood vessels
and products inside the spleen
are going to be held in
by a very thin capsule.
02:16
And that's going
to be important,
we talk about
pathology of the spleen.
02:20
And the spleen really
serves two functions.
02:23
And it has two different components
for these two different functions.
02:27
The smaller component by volume
is something called the white pulp.
02:31
And that has an
immunologic function,
it's going to be composed
mostly of white blood cells.
02:37
The majority of this means
can be composed of the red pulp,
and that's going to serve the
hematologic function of the spleen.
02:46
So let's take a look at this
hematologic role of the red pulp.
02:50
The bone marrow is
making new red blood cells
more or less continually.
02:56
That's because the red
blood cells lacking a nucleus
aren't going to divide
into more red blood cells.
03:03
In fact,
they only have a lifespan
in the circulation
of about 120 days.
03:09
And as they're circulating
through the body,
they're going
through the spleen,
and basically getting
checked to see if they're
still viable and should
be long in circulation,
because they're
still functional,
in which case,
they can go back until they're not.
03:24
Or if they're too old,
or they're damaged,
then the spleen is going to
take them out of circulation
by phagocytosing
them with those special
cell eaters called macrophages.
03:38
Here we have a posterior view
of how the spleen sits in the body.
03:44
So we sort of faded
out the skin a little bit
to see a little bit
of the ribcage here.
03:49
And the spleen sits
roughly between ribs
9 and 11 under the
unusual circumstances.
03:56
And that's a really good
thing because the spleen,
as we mentioned, has a very
thin capsule and it's full of blood.
04:02
So this protection, if you will
of the ribs is pretty important.
04:08
Unfortunately,
there are many conditions,
such as various
leukemias or infections
such as mono that you
may have heard about
an Epstein-Barr virus infection,
that can cause the
spleen to become much
more enlarged something
called splenomegaly.
04:27
And when it gets enlarged,
it can now extend
beyond the protection
of the ribcage.
04:34
And now it's out
into the abdomen
where there's no
bony protection.
04:40
And that's important,
because the capsule
being so thin makes
it prone to rupture.
04:46
And that's why if
you've ever heard about
someone who's had mono
or you've had it yourself,
you've been told you're
not supposed to participate
in contact sports for,
you know, two to four weeks.
04:57
This is why.
04:58
Because now this
enlarge arch spleen,
in addition to being under
pressure from the enlargement
is also now dipping below
the protection of the ribcage
and makes it much
more prone to rupture.
05:11
And unfortunately because
the capsule is so thin,
usually when it ruptures the
spleen needs to be taken out
altogether in a process
called a splenectomy.