00:01
Now, let's take a closer look at the spinal cord
and the peripheral nervous system or PNS.
00:08
Here, we have a typical cross-section
of the spinal cord.
00:12
The arrangement of gray and white mater is
somewhat the opposite of what we see in the brain
and that the gray matter of the spinal cord
tends to be more deep or inside
and the outside portion is going to
be mostly the white matter.
00:28
Again, the gray matter represents
where cell bodies and nuclei are
and the white matter, where myelin
of axons is going to be located.
00:38
We also find in the middle a very small
opening called the central canal.
00:44
And this is where cerebrospinal fluid flows
and this is the equivalent of ventricles in the brain.
00:53
We also have the same type of meninges
that we saw in the brain starting with the pia mater
which is directly attached to
the surface of the spinal cord.
01:03
Then, the arachnoid.
And between the arachnoid and pia mater,
we still have subarachnoid space
and just as with the brain,
the subarachnoid space is also going to
be filled with cerebrospinal fluid.
01:19
Then, finally, the outermost layer of meninges,
the strongest layer is the dura mater.
01:26
And all along the course of the spinal cord,
there will be spinal nerves exiting out the spinal cord
through the vertebral column to branch into
all of the peripheral nervous system.
01:40
The spinal cord doesn't actually run all the way
down the length of the vertebral column though.
01:47
As you can see here, it actually starts to
end early on into the lumbar area,
so, that by the time you get to the L2 or L3, L4 area,
it's really just a collection of individual nerves
rather than a solid cord and it gets
the name cauda equina
because it looks like a horse's tail
and that's essentially what cauda equina means.
02:13
This is pretty useful when it comes to the process
of carrying out a lumbar puncture.
02:19
Because sometimes, there are indications
for sampling cerebrospinal fluid
and sampling it from the brain is for
the most part impossible or dangerous
and getting it from the spinal cord can be difficult
if you're going to hit the actual spinal cord itself.
02:37
So, knowing that the spinal cord ends
in the cauda equina at the very distal end,
we can target that area when
we take a lumbar puncture.
02:47
By locating the appropriate lumbar vertebra
and taking a posterior approach through the dura,
through the arachnoid into the subarachnoid
space where the CSF is,
not only can we have relatively easy access
compared to other parts of the body,
but we don't have to worry about damaging the spinal cord
because it's ended a few levels up higher from here.
03:16
Here, we're going to look at the various parts of the spinal cord
which correspond to the overlying vertebral body,
very similar to the way lobes of the cerebrum
corresponded to the overlying skull bones.
03:30
So, in the area of the cervical vertebra,
we have the cervical part.
03:34
In the area of the thoracic vertebra,
we have the thoracic part.
03:40
Similarly, we have lumbar nerves
in the area of the lumbar spine.
03:48
And then, by the time we get to the sacral area,
they are, of course, just individual nerves.
03:53
It's not really the spinal cord anymore
but we have sacral nerves in the area of the sacrum.
04:00
And then, there's a single coccygeal nerve down
by the area of the coccyx which is the smallest,
most terminal portion of the vertebral column.
Here's something that will help exemplify
the concept of spinal nerves hopefully, pretty well.
And it's the idea of a dermatome.
04:19
A dermatome refers to a region of skin whose
sensation is supplied by a particular spinal nerve.
04:27
And so here, we can see in a map form of sorts,
the dermatomes provided by the cervical spinal nerves.
04:36
So, we know that if there's any loss
of sensation in this area in red,
it can be traced to some sort of nerves supplying
one of the areas of the cervical spinal cord.
04:49
Similarly, here, we have the thoracic dermatomes.
So, we see the areas innervated by thoracic spinal nerves.
04:58
Then, we see the lumbar spinal nerves
and the sacral and coccygeal nerves.
05:06
Dermatomes have a lot of clinical significance
beyond just testing for sensory deficits.
05:12
For example, there's something
called shingles which is a virus
that's actually a reactivation of a virus
that lives inside, usually, for a long time of a nerve.
05:26
It can be dormant inside of this nerve without
any symptoms until it's reactivated as shingles
and when it does so, because it's inside a given nerve,
it will outline the area of a dermatome for you.
05:40
So, for example, here's an example of shingles
along a thoracic dermatome.
05:45
So, the distribution of this rash just by looking
at it because it's this particular strip of skin
tells you it's along a thoracic dermatome and it tells you that
that virus was hiding inside one of the thoracic spinal nerves.
06:01
This also relates to
something called referred pain.
06:05
And referred pain is something that is
pretty common in certain pathologies.
06:12
So, with all of these nerves supplying a dermatome,
they're all coming back to a particular spinal level.
06:21
But there are other things coming back via spinal nerves and
other types of nerves to that particular spinal level as well.
06:32
For example, the skin of, for example,
maybe the area of the shoulder,
might be going back to this
portion of the spinal cord.
06:43
But that level of the spinal cord may also be
receiving sensory input from the heart.
06:51
And if there is, for example, a heart attack,
that sensory information from the heart
coming into the same level as the
sensory information of skin from the shoulder
might get confused and you might
get what's called referred pain.
07:05
Whereas the pain maybe since is coming from the skin
of the shoulder when it's really coming from the heart.
07:12
And that's why it's important
to know about referred pain
because sometimes, referred pain
may be indicating something more serious.
07:21
And for example, here's a map of some
of the areas on the skin where pain
may be referred from organs that you might not
expect based off of their anatomic location.
07:32
And again, that all has to do with the fact
that the nerves from both that patch of skin
and the organ that's referring pain to
that area are going back to the same spinal level.