00:00
In this presentation, we're going to talk about an emergency situation that happens
in patients that have diabetes and that is called diabetic ketoacidosis more
commonly referred to as DKA. So we're going to talk about what the definition of
DKA is, some causes and risk factors, presentation, what it's going to look like
when patients have DKA, and we're going to talk about diagnosis and assessment.
00:29
So, what is diabetic ketoacidosis? It is defined by the presence of all of the
following in a patient with diabetes. So, the patient has hyperglycemia. So
normally we would hope that a diabetic patient is really going to keep control of
their insulin management and they're going to keep that blood sugar in a good
range, but sometimes it happens that that blood sugar gets out of control, it gets
too high, and generally if it's greater than 200 it's going to start to cause some
problems. You also have to have the presence of metabolic acidosis. So, this is
going to be explained a little bit more in detail later, but just remember that when
you have metabolic acidosis that means the pH of your blood is going to be too
low and for diabetic ketoacidosis it's really we're looking for that venous pH and
it's going to be less than 7.3. You can also look at the bicarbonate level of a patient
and if that's less than 15 that will also mean that your patient is acidotic. The last
thing that we're looking for for DKA is ketosis. Right there in the name, right,
diabetic ketoacidosis. I love it when they make it simple for us. You have acidosis
and you have ketosis, right there in the name. So, the presence of ketones in the
blood or the urine. If you are measuring ketones in the blood, you're measuring
beta-hydroxybutyrate, I know that's a mouthful, but you'll get used to seeing that
term and when you're measuring the presence of ketones in the urine that's when
you're dipping the urine and you're looking to see for those ketones. We're going to
talk about some precipitating factors for DKA or things that might cause a patient
that has diabetes to go in to DKA. There are a couple of categories of things that
can cause DKA. So, if a patient is put on a particular drug, is given a prescription
for something like corticosteroids, maybe high doses of thiazides, some of the
second generation antipsychotics, those are examples of drugs that can precipitate
or cause DKA. Many times children present with DKA because they've had an
illness, perhaps they've had a respiratory illness or they have had a stomach bug,
something that is making them not feel very well and that could cause the
symptoms to get worse and can cause children to go in to DKA. Endocrine
dysfunction can also precipitate DKA. Sometimes it's a new diagnosis of diabetes
and so the diabetes is not being controlled at all and it presents with DKA.
03:17
Non-compliance with insulin for people who haven't established diagnosis of diabetes,
sometimes teenagers don't want to take their insulin and they will just let that blood
sugar get higher and higher until they start having difficulty and present with
DKA. Sometimes it's because the insulin therapy is inadequate. Maybe they needed
adjustment in their doses. So, again, when you think of teenagers who are going
through puberty, we know those hormones are going all over the place and insulin
is a hormone. So, we really have to make sure that worst thing on top of the dosing
and if they've had big changes and haven't had changes in their insulin dosing,
then they may present with DKA even though they're taking the dose they we're
prescribed. So it's not always the teenager's fault. Additionally, there are a few
conditions that can cause decreased effectiveness of insulin that isn't necessarily
associated with diabetes so acromegaly, thyrotoxicosis, and cushing's disease are a couple of examples of this.