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Alpha-Glucosidase Inhibitors – Oral Antidiabetic Medications (Nursing)
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Slides 07-05 DiabeticMedications III Oral Antidiabetics and Non-Insulin SubQ.pdf
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00:01 Our fifth family are the alpha-glucosidase inhibitors, okay? These names just keep getting longer and longer. 00:10 But let's start with a fun question. 00:12 What is borborygmus? All right? What is borborygmus? The answer? Those are those weird stomach noises and rumbling, and that's one of the bizarre side effects of alpha-glucosidase inhibitors. 00:33 So, alpha-glucosidase is an enzyme that breaks down carbohydrates into monosaccharides. 00:39 So, in a healthy body, that's what alpha-glucosidase does. 00:43 It's an enzyme. 00:44 And when I eat a carbohydrate, it has to be broken down into monosaccharides, so I can use it. 00:49 Alpha-glucosidase inhibitors work in the intestines and they delay the dietary carbohydrate absorption. 00:58 So, that's where those weird noises come from. 01:01 Anytime you start messing with the digestive process, you're going to get some weird things. 01:07 If I have delayed carbohydrates, it's going to end up with bacterial fermentation. 01:13 Might be another source of those weird stomach noises. 01:18 So, what do we use these guys for? Well, we can use them by themselves. 01:22 There's no risk for hypoglycemia. 01:25 Wait a minute. 01:26 What other medications have we discussed that have a risk of hypoglycemia? See if you can write that note in your margin now. 01:40 We can also use these with combination therapy, but now when we add these drugs in like insulin or sulfonylureas, because those drugs do have a risk of low blood sugar, now your patient is at risk for low blood sugar. 01:55 Now, this is just an extra side for you, to help you kind of remember, alpha-glucosidase inhibitors, we make the "G" and the "I" really big to help you remember, we can have some liver issues, those weird stomach noises. 02:09 We can also have problems with iron. 02:12 Now, long-term high-dose therapy, you might have reversible damage to that liver, okay? We might be able to fix it once you're off it. 02:19 So, you're going to see that effect, the problem with your liver, the higher the dose and your longer that you're on it. 02:25 Those weird, GI stomach noises, you'll likely see that in the beginning of the doses. 02:30 So we don't widely use this drug in the United States, but we wanted you to be aware of it.
About the Lecture
The lecture Alpha-Glucosidase Inhibitors – Oral Antidiabetic Medications (Nursing) by Prof. Lawes is from the course Endocrine Medications (Nursing).
Included Quiz Questions
What is the mechanism of action of alpha-glucosidase inhibitors?
- They delay the breakdown of carbohydrates into monosaccharides and thus delay dietary absorption and digestion.
- They delay the breakdown of proteins into monosaccharides and thus delay dietary absorption and digestion.
- They enhance the breakdown of carbohydrates into monosaccharides and thus delay dietary absorption and digestion.
- They delay the breakdown of carbohydrates into polysaccharides and thus enhance dietary absorption and digestion.
What side-effects will the nurse include when educating a client about alpha-glucosidase inhibitors?
- Borborygmus, hepatotoxicity, and anemia due to iron malabsorption
- Nausea/vomiting, tachycardia, and hypotension
- Hypoglycemia, renal insufficiency, and bloating
- Borborygmus, bone fragility, and hypotension
Author of lecture Alpha-Glucosidase Inhibitors – Oral Antidiabetic Medications (Nursing)
Prof. Lawes
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