Pathology I is a foundational course designed to introduce students to the basic mechanisms of disease processes at the cellular and tissue levels. The course explores the fundamental pathological alterations that occur in response to cellular injury, inflammation, hemostatic disturbances, immune-mediated diseases, and infections, as well as the pathogenesis of neoplastic disorders and cardiovascular diseases. Through lectures and case studies, students will develop the ability to correlate morphological changes with functional consequences in various disease states.
The course emphasizes the molecular, biochemical, and cellular mechanisms underlying disease processes, with special attention to the dynamic relationships between etiology, pathogenesis, and clinical manifestations. Students will learn to recognize and interpret essential pathological changes using microscopic specimens, gross pathology, and clinical laboratory findings, thereby establishing the critical thinking skills necessary for understanding disease progression and therapeutic implications in clinical practice.
Learning objectives
After the completion of this course, you will be able to:
- Describe the cellular and molecular mechanisms of reversible and irreversible cell injury, and correlate these changes with their morphological and functional manifestations
- Analyze the processes of acute and chronic inflammation, including mediators, cellular events, and systemic effects, and their roles in tissue damage and repair
- Explain the mechanisms of hemostasis, thrombosis, embolism, and coagulation disorders, and their pathophysiological consequences
- Evaluate the immunopathological processes underlying hypersensitivity reactions, autoimmune diseases, and immunodeficiency disorders
- Analyze host-pathogen interactions and the pathogenesis of common infectious diseases, including mechanisms of microbial virulence and host defense
- Distinguish between benign and malignant neoplasms based on their molecular characteristics, morphological features, and biological behavior
- Interpret the pathological basis of major cardiovascular disorders, including atherosclerosis, ischemic heart disease, hypertensive heart disease, and congenital heart defects
- Apply pathological terminology accurately when describing disease processes and tissue alterations
- Correlate pathological findings with clinical manifestations and laboratory data in common disease states
- Evaluate the impact of pathological processes on prognosis and therapeutic approaches in clinical scenarios
Course outline
- Cellular Injury
- Acute and Chronic Inflammation
- Hemostasis
- Immune-mediated Diseases
- Host–pathogen Interaction
- Neoplasia
- Cardiovascular Pathology
