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VATER/VACTERL Syndrome and Lung Hypoplasia – Lung Development

by John McLachlan, PhD
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    00:00 oesophageal atresia. I mentioned complex syndromes and VATER or VACTERL syndrome, maybe one of those, where a baby may be born with a whole combination of things which have not gone well.

    00:12 So there may have anomalies of the vertebrae. The anus may be blind ending. There may be cardiovascular problems.

    00:20 One might have a tracheo-oesophageal fistula. There may also be oesophageal atresia, and you’ll note that the acronym has the American spelling of oesophagus.

    00:28 There may be a renal abnormalities and limb anomalies as well. This particular set, this constellation of conditions is called a VATER or VACTERL syndrome. Lungs may also fail to develop.

    00:45 One cause of this is a diaphragmatic hernia, a hole in the developing hernia.

    00:51 And this, perhaps more frequently on the left-hand side, allows part of the gut, in this case, the colon, to enter into the pleural cavity. If this happens in early stage, the lung will be underdeveloped. It lacks the space to develop fully, and therefore, it will always remain smaller than it should be. And this underdevelopment of the lung on the affected side means that the adult may be more vulnerable to lung problems later in life because one of the lungs is smaller than it would normally be. In addition, we may also have agenesis, failure of the


    About the Lecture

    The lecture VATER/VACTERL Syndrome and Lung Hypoplasia – Lung Development by John McLachlan, PhD is from the course System-Specific Embryology with John McLachlan.


    Author of lecture VATER/VACTERL Syndrome and Lung Hypoplasia – Lung Development

     John McLachlan, PhD

    John McLachlan, PhD


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