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Tetralogy of Fallot – Blood Vessel and Heart Abnormalities

by John McLachlan, PhD
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    00:01 Our next defect is the tetralogy of fallot, whereas, in the previous ones, we looked at the ventricular septal defect, which is a defect of the partitioning of the ventricles.

    00:11 Atrial septal defect is a defect of partitioning of the atria. The tetralogy of fallot is a defect of septation in the truncus arteriosus in the outflow tract from the heart.

    00:24 It’s called tetralogy because there are four major consequences, and these overlap with each other.

    00:30 So it’s hard to look at them in isolation. So try and hold an overall picture in your mind of what’s happening as a result of the disturbance of septation in the outflow tract of the heart.

    00:43 The first one is identified in the diagram as an overriding aorta. So the entrance to the aorta is enlarged and spreads out more than it would be, normally and this may be visible in ultrasound views. You generally will find a ventricular septal defect although this may be harder to see because of the overriding aorta in a four-chamber view of the developing heart.

    01:10 There will also be a narrowing stenosis, as we call it, between the right ventricle and the pulmonary artery. This pulmonic stenosis makes it harder for blood to leave the ventricle.

    01:23 As a consequence, the muscle of the right ventricle may be overdeveloped. So, you have right ventricular hypertrophy as a consequence of that pulmonic narrowing, that pulmonic stenosis leading into the pulmonary circulation. Now then, what about patent ductus arteriosus?


    About the Lecture

    The lecture Tetralogy of Fallot – Blood Vessel and Heart Abnormalities by John McLachlan, PhD is from the course System-Specific Embryology with John McLachlan.


    Author of lecture Tetralogy of Fallot – Blood Vessel and Heart Abnormalities

     John McLachlan, PhD

    John McLachlan, PhD


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