Regulation of Iron Transport by Kevin Ahern, PhD

Name: Regulation of Iron Transport
Uploaded: 2016-10-26
Duration: 8 min 49 s
Description: The lecture Regulation of Iron Transport by Kevin Ahern, PhD is from the course Amino Acid Metabolism.

About the Lecture

The lecture Regulation of Iron Transport by Kevin Ahern, PhD is from the course Amino Acid Metabolism.

Included Quiz Questions

Which of the following is true regarding the iron response element (IRE)?

It is bound by the IRE-BP when iron concentration is low.
It is a protein.
It binds to iron when the iron concentration is high.
It occurs near the 3' end of the ferritin mRNA.
It allows the ribosome to perform translation when bound to the IRE-BP.

Which is true regarding the binding of the IRE-BP to the transferrin receptor mRNA?

It occurs at the 3’ end.
It protects the 5’ end from nuclease degradation.
It reduces the synthesis of the receptor.
It binds to the transferrin mRNA when iron concentrations are high.
It allows nucleases to degrade the transferrin mRNA.

What happens to ferritin regulation at the low levels of iron inside the cell?

The IRE-BP binds to the IRE of the ferritin mRNA and blocks the synthesis of ferritin protein.
The IRE-BP binds to the iron and halts the synthesis of ferritin protein.
The IRE-BP binds to the iron and facilitates the synthesis of the ferritin protein.
The IRE-BP binds to the iron and facilitates the binding of iron with the ferritin mRNA.
The IRE-BP binds to the IRE of the ferritin mRNA and allows for the synthesis of the ferritin protein.

How do the high concentrations of iron regulate the transferrin receptor protein synthesis?

At high concentrations of iron, the binding of IRE-BP to iron makes transferrin receptor mRNA susceptible to nuclease attack and prevent transferrin receptor protein synthesis
At high concentrations of iron, the binding of IRE-BP to transferrin receptor mRNA facilitates transferrin receptor protein synthesis
At high concentrations of iron, the binding of iron to IRE of transferrin receptor mRNA facilitates the synthesis of transferrin receptor protein
At high concentrations of iron, the binding of IRE-BP to iron and IRE of mRNA facilitates the synthesis of transferrin receptor protein
At high concentrations of iron, the binding of IRE-BP to iron facilitates the synthesis of transferrin receptor protein