Leucine (LEU), Valine (VAL), Isoleucine (ILE) and Histidine (HIS) Metabolism
About the Lecture
The lecture Leucine (LEU), Valine (VAL), Isoleucine (ILE) and Histidine (HIS) Metabolism by Kevin Ahern, PhD is from the course Amino Acid Metabolism. It contains the following chapters:
- Leucine (LEU)/Valine (VAL)/Isoleucine (ILE) Metabolism
- Histidine (HIS) Metabolism
Included Quiz Questions
Which of the following is true of branched chain amino acid synthesis?
- It is regulated by threonine deaminase.
- It begins with α-ketobutyrate.
- It favors isoleucine when valine is low.
- Valine and isoleucine pathways involve adding a two-carbon piece to pyruvate.
- They start with decarboxylation and the addition of a three-carbon piece.
Which of the following apply to branched chain amino acid catabolism?
- Leucine metabolism starts with decarboxylation.
- Breakdown of branched-chain amino acids involves transamination.
- It produces NAD+.
- It produces NADH.
- When defective, it results in maple syrup urine disease.
Which of the following is true regarding histidine metabolism?
- It overlaps with nucleotide metabolism.
- It arises from tryptophan metabolism.
- It involves 15 steps.
- Isoleucine inhibits this pathway.
- It is a very simple pathway.
The branched-chain ketoaciduria (maple syrup urine disease) is caused due to the deficiency of which enzyme?
- Branched-chain alpha-keto acid dehydrogenase complex (BCKDC).
- Tyrosine transaminase.
- 4-fumarylacetoacetase.
- Homogentisate oxidase.
- Threonine deaminase.
Histidine amino acid synthesis is controlled by a feedback mechanism involving the interaction of which of the following?
- ATP-phosphoribosyltransferase and histidine.
- Threonine deaminase and threonine.
- Threonine deaminase and histidine.
- ATP-phosphoribosyltransferase and threonine.
- Tyrosine transaminase and histidine.
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Author of lecture Leucine (LEU), Valine (VAL), Isoleucine (ILE) and Histidine (HIS) Metabolism
Kevin Ahern, PhD
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