Anti-HIV Agents: CCR5 Antagonist – Antiviral Drugs

by Pravin Shukle, MD

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    00:00 Let's move on to the last class of anti-HIV agents.

    00:04 These are the CCR5 or CCRV, V meaning the Roman numeral for 5 Antagonist.

    00:12 So sometimes they are called CCRV.

    00:14 Sometimes they are called CCRV's.

    00:15 The CCRV protein is a special kind of molecule on the surface of most white blood cells.

    00:22 It is that to which HIV particles will bind to.

    00:26 So if you competitively inhibit the CCR5 molecule with these drugs, what will happen is the HIV virus cannot enter the cell because that cannot bind to the cell surface.

    00:38 The CCR5 antagonist are inhibiting a protein called CCR5 or CCRV.

    00:45 It's a transmembrane chemokine receptor.

    00:48 And it's involved in the envelope binding of HIV viruses.

    00:54 Now these drugs like miraviracor are targeting CCR5 and then inhibiting that chemokine receptor.

    01:03 There's minimal cross resistance with other medications which is quite nice.

    01:07 Enfurvitide is another agent in this class.

    01:10 Now it binds to a slightly different part.

    01:14 You've probably heard about the gp41 subunit.

    01:17 I believe that your microbiology lectures have spoken about this when they are talking about HIV.

    01:23 So this drug binds to the gp41 subunit of the viral envelope.

    01:28 And it actually causes inhibition and reduction in your ability to create envelopes for the HIV virus.

    01:35 There's no cross resistance with this so it's kind of nice.

    01:39 In terms of resistance itself, it's coded directly at the env gene.

    01:46 So that's a good question.

    01:48 Because remember we spoke about another agent being developing it's resistance to the pol gene.

    01:53 This one is different.

    01:55 It's the env gene and it's convenient because it sounds very much like the name of the drug enfurvitide.

    About the Lecture

    The lecture Anti-HIV Agents: CCR5 Antagonist – Antiviral Drugs by Pravin Shukle, MD is from the course Antimicrobial Pharmacology.

    Included Quiz Questions

    1. Fusion inhibitors
    2. Viral release
    3. DNA transcription
    4. Packaging and assembly
    5. Early protein synthesis
    1. Env gene
    2. Pol gene
    3. Viral mutation to enfuvirtide has not been found
    4. Rev gene
    5. Gag gene

    Author of lecture Anti-HIV Agents: CCR5 Antagonist – Antiviral Drugs

     Pravin Shukle, MD

    Pravin Shukle, MD

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