X-linked Inheritance
About the Lecture
The lecture X-linked Inheritance by Georgina Cornwall, PhD is from the course Single-Gene Disorders.
Included Quiz Questions
What is the probability of hemophilia A in a male offspring if the mother is a carrier?
- 50%
- No probability of an affected male offspring
- 25%
- 75%
- 100%
What is the probability of hemophilia A in a female offspring if the mother is a carrier and the father is normal?
- No probability of an affected female offspring
- 25%
- 50%
- 75%
- 100%
Why might a carrier female display mosaicism in an X-linked recessive disorder?
- Each cell has the ability to form a Barr body with the normal chromosome or with the mutant chromosome.
- They have three X-chromosomes and two will compensate for the mutant allele.
- They have a translocation of the mutant type allele to the wild type chromosome so both alleles can be expressed.
- Two Barr bodies are formed so neither X-chromosome is expressed.
- Transcription factors favor binding the Barr body causing a variable yield of proteins.
Which of the following terms best describes sex-linked genes in a normal human male?
- Hemizygosity
- Homozygosity
- Heterozygosity
- Ambiguity
- Haploidy
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Author of lecture X-linked Inheritance
Georgina Cornwall, PhD
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Very in-depth discussion of X-linked inheritance. A very good resource for studying for exams on human genetics.
