Whipple's Disease and Tropical Sprue

00:01 Middle aged men, PCR analysis for bacterial DNA is confirmatory.

00:06 Diarrhea, abdominal pain, arthritis, neurologic deficit, lymphadenopathy, remember this is a bacterial disease.

00:14 Diagnosis here would include periodic acid schiff where you would find these granules in your macrophages and the management for this would be antibiotics such as cotrimoxazole.

00:31 Tropical Sprue, as the name implies, these would be tropical regions, associated with megaloblastic anemia.

00:38 Tropical Sprue, some would say that it is infectious but exact cause and etiology is pretty much unknown, but then the reason for the folic deficiency resulting in megablastic anemia, that´s the part they were unclear about.

00:51 So the most important symptom is something that pretty much remains a mystery or idiopathic.

00:57 Here, the pathology similar to Celiac Sprue, but has nothing to do with gluten.

01:05 So you have three conditions here in which you wanna keep in mind when you´re dealing with Celiac just to make sure.

01:10 Celiac disease, we know everything about.

01:13 Next, we take a look at Whipple but that´s your Tropheryma, that´s your bacteria periodic acid schiff. Yes, diarrhea there as well.

01:21 Tropical Sprue, here once again, it seems as though that it destroys the intestine, megaloblastic anemia, unknown cause maybe perhaps infectious because of this, tetracycline antibiotic but more importantly, the folate.

01:36 Not the B12 deficiency here that you find in Tropical Sprue.