Clinical Application of Renal Blood Flow (Part 2)

by Carlo Raj, MD

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    Continuing our discussion of, clinical application of renal blood flow. We are going to take that information that we have seen prior, with that table and make sure that you then associate it with that picture where for example we looked at Bowman's space hydrostatic pressure being increased with obstruction such as BPH may be a renal stone or there is increase in oncotic pressure in the Bowman's space in those dealing with something like minimal change disease, the most common cause of nephrotic syndrome in a child. Continuing our discussion and putting in a little bit more detail, but just enough where you are able to create a story for yourself. Lets take a look at this picture. Now in the very beginning, we talked about the anatomy of renal blood flow. We began by looking at the renal artery headed towards where the hilum of that kidney. Next, the interlobar and you had your interlobular. In other words, that would be your, well, arcuate gives rise to your corticoradiate. This then gives rise to your afferent arteriole. You tell me as to what normally keeps the afferent arteriole open? Prostaglandin. Keep that in mind. Whereas on the efferent side, we continue the blood flow. There is a very important hormone known as angiotensin-II, which then causes preferentially vasoconstriction at the efferent arteriole. There is a balance that is taking place constantly between the afferent and efferent known as autoregulation in which you will then have blood flow well depending, as the range of blood pressure, maybe approximately from 40 to 140 where that blood flow will remain the same so that's your proper GFR. Now on the efferent side, we are moving beyond the arteriole, now what's really interesting about this, is the fact the afferent, what is...

    About the Lecture

    The lecture Clinical Application of Renal Blood Flow (Part 2) by Carlo Raj, MD is from the course Renal Pathology. It contains the following chapters:

    • Changes in Glomerular Dynamics
    • Renin-Angiotensin-Aldosterone-System

    Author of lecture Clinical Application of Renal Blood Flow (Part 2)

     Carlo Raj, MD

    Carlo Raj, MD

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