00:00 Okay, let's do a question. 00:03 The following is true about the NNRTI's, the Non-Nucleoside Reverse Transcriptase Inhibitors. 00:10 A) They bind to the same reverse transcriptase site as the nucleoside reverse transcriptase inhibitors. 00:19 B) They require phosphorylation to be activated. 00:23 C) They competitively inhibit nucleoside triphosphates. 00:28 D) There is cross resistance with the NRTI's. 00:33 And E) resistance is due to pol gene mutations that can occur quickly in monotherapy. 00:43 Great, you picked E. 00:44 So I mentioned before that the pol gene is responsible for point mutations that reduce the effectiveness of the non-nucleoside reverse transcriptase inhibitors. 00:55 This is the kind of question that is "fair game" on exams. 00:58 And I know that it looks like a hard question. 01:00 But if you remember the pol gene and env gene that we talked about, you'll do really well on these exams. 01:07 Now these are some really salient points that I want you to remember when you're studying. 01:12 The NNRTI's do not bind to the same sites as the NRTI's. 01:17 So A is not correct. 01:20 Number 2, while NRTI's require phosphorylation, the non-nucleoside agents don't. 01:27 Because they're not nucleosides. 01:29 Remember that nucleosides have to be phosphorylated. 01:32 You want guanine. 01:33 You want guanine triphosphate . 01:35 You want adenosine, you want adenosine triphosphate, right. 01:38 B is incorrect. 01:40 The nucleosides will completely and competitively inhibit nucleoside enzymes. 01:46 But non-nucleosides will not. 01:48 So therefore, the C choice was incorrect. 01:51 Now because they don't bind to that same site cross resistance is rare. 01:57 So therefore D was incorrect. 01:58 And the correct answer is E which is the pol mutation.
The lecture Questions about Anti-HIV Agents – Antiviral Drugs by Pravin Shukle, MD is from the course Antimicrobial Pharmacology.
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