Questions about Anti-HIV Agents – Antiviral Drugs

by Pravin Shukle, MD

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    Okay, let's do a question. The following is true about the NNRTI's, the Non-Nucleoside Reverse Transcriptase Inhibitors. A) They bind to the same reverse transcriptase site as the nucleoside reverse transcriptase inhibitors. B) They require phosphorylation to be activated. C) They competitively inhibit nucleoside triphosphates. D) There is cross resistance with the NRTI's. And E) resistance is due to pol gene mutations that can occur quickly in monotherapy. Great, you picked E. So I mentioned before that the pol gene is responsible for point mutations that reduce the effectiveness of the non-nucleoside reverse transcriptase inhibitors. This is the kind of question that is "fair game" on exams. And I know that it looks like a hard question. But if you remember the pol gene and env gene that we talked about, you'll do really well on these exams. Now these are some really salient points that I want you to remember when you're studying. The NNRTI's do not bind to the same sites as the NRTI's. So A is not correct. Number 2, while NRTI's require phosphorylation, the non-nucleoside agents don't. Because they're not nucleosides. Remember that nucleosides have to be phosphorylated. You want guanine. You want guanine triphosphate . You want adenosine, you want adenosine triphosphate, right. B is incorrect. The nucleosides will completely and competitively inhibit nucleoside enzymes. But non-nucleosides will not. So therefore, the C choice was incorrect. Now because they don't bind to that same site cross resistance is rare. So therefore D was incorrect. And the correct answer is E which is the pol mutation. ...

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    The lecture Questions about Anti-HIV Agents – Antiviral Drugs by Pravin Shukle, MD is from the course Antimicrobial Pharmacology.

    Author of lecture Questions about Anti-HIV Agents – Antiviral Drugs

     Pravin Shukle, MD

    Pravin Shukle, MD

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