Purine de novo Metabolism Regulation
About the Lecture
The lecture Purine de novo Metabolism Regulation by Kevin Ahern, PhD is from the course Purine and Pyrimidine Metabolism.
Included Quiz Questions
Which of the following is true regarding the regulation of purine metabolism? Select all that apply.
- Both of the enzymes acting on IMP are feedback inhibited.
- PRPP amidotransferase is fully inhibited by either AMP or GMP.
- Low phosphate and AMP will inhibit the first enzyme of the pathway.
- ATP inhibits Adenylosuccinate synthetase.
- IMP dehydrogenase is inhibited by GMP.
Which of the following enzyme does NOT participate in the regulation of purine synthesis in the cells?
- Nucleoside diphosphate kinase
- PRPP synthetase
- PRPP amidotransferase
- IMP dehydrogenase
- Adenylosuccinate synthetase
Which of the following is NOT matched correctly?
- Nucleoside diphosphate kinase — inhibited by an excess of ribose-5-phosphate.
- PRPP synthetase — inhibited by high levels of phosphate and ADP.
- PRPP amidotransferase — partly inhibited by AMP or GMP, but fully inhibited by both AMP and GMP.
- IMP dehydrogenase — inhibited by GMP to stop GTP synthesis.
- Adenylosuccinate synthetase — inhibited by AMP to stop ATP synthesis.
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Author of lecture Purine de novo Metabolism Regulation
Kevin Ahern, PhD
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beautifuly explained. thankyou!! Every point in every step was explained nicely.
I loved how I understood the bigger picture in the end of the lecture
