Proximal Convoluted Tubule (PCT): Pathophysiology

by Carlo Raj, MD

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    Up until now we have looked at overview of the nephron and we have introduced the different parts of the nephron and I have gone through an overview. And at some point if you got a little confused or perhaps even tripped up with some of the information that I have given you, not to worry, reinforcement. So here we will walk into and dive into further detail of each segment of the nephron and go through all the relevant information so that you can get your questions on any aspect of medicine on the nephron absolutely correct. So let us take a look at the PCT in that respect. Once again, to review, take a look at this. Obviously, I am not going to spend time going through each one in details, but I will go through the details of what I referred to. For example, the carbonic anhydrase and its inhibition and what that means to you? Stop here for one second and what does that mean to you if you inhibit that enzyme? You are getting rid of your bicarb. Why might you want to do that? Do you remember our discussion on high altitude? How fast are you breathing? Very quickly. Blowing off the carbon dioxide so maybe perhaps you might want to on purpose, help your patient by inhibiting the carbonic anhydrase so that patient can then compensate by getting rid of that bicarb in the kidney. At this point, you should be able to figure out what the figure looks like in its organization pattern? I have established that over and over again in previous discussions. For example, on the left is your urine, in the middle is your cell and on the right is your interstitium, moving towards your blood. We have also...

    About the Lecture

    The lecture Proximal Convoluted Tubule (PCT): Pathophysiology by Carlo Raj, MD is from the course Renal Pathology. It contains the following chapters:

    • Proximal Nephron
    • Proximal Convoluted Tubular Mechanics
    • Correlations

    Author of lecture Proximal Convoluted Tubule (PCT): Pathophysiology

     Carlo Raj, MD

    Carlo Raj, MD

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