Anti-HIV Agents: Protease Inhibitors – Antiviral Drugs

by Pravin Shukle, MD

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    Let's move on to Protease Inhibitors. Now protease inhibitors are involved in the late stage of protein synthesis and processing. So it's after the nucleic synthesis has already occurred there are other proteins that are being manufactured that are necessary for the next step which is packaging and assembly of the virus quote. Now protease inhibitors are part of the components used in HAART therapy. There are significant disorders in carbohydrate metabolism that are induced by the protease inhibitors. Now we are not sure how these agents work, but we think that there maybe an inhibition of lipid regulating proteins that are site similar to HIV protease. And one of the things that we have to be aware of is that 50% of our patients can actually get a protease inhibitors syndrome or PI syndrome on patients who are taking these PI's for over one year. Now what you see is increased truncal obesity. Kind of that buffalo hump, the Quasimodo hump that we often talk about. And we can see gynecomastia. We also see facial and peripheral lipodystrophy. So there's often some increase fat development in the face and they have a rounder face. Very similar to the kind of changes we see with excess prednisone dosing. We also see hyperglycemia and insulin resistance. And we can see a rise in the serum LDL and tryglyceride values. Now some of the agents are once daily dosing. They require an acidic environment. They can penetrate blood brain barriers. So we sometimes see them in the central nervous system and in the seminal fluid which is quite relevant in terms of sexual activity for our patients. It is also excreted in the bio. So we tend to see the protease inhibitors distribute to most tissues and most fluids. In terms of...

    About the Lecture

    The lecture Anti-HIV Agents: Protease Inhibitors – Antiviral Drugs by Pravin Shukle, MD is from the course Antimicrobial Pharmacology.

    Author of lecture Anti-HIV Agents: Protease Inhibitors – Antiviral Drugs

     Pravin Shukle, MD

    Pravin Shukle, MD

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