slides I've shown you and see if you can pick
out what blood form it is.
Natural infection, natural immunity to infection,
is imperfect. You are not protected, even
though you do respond, you are not protected
against reinfection. So this is the hallmark
of malaria. Throughout your whole life, if
you live in an endemic area, you will be reinfected
over and over and over again. And as I said,
this leads to a miserable life in which you
can't do anything productive.
How do you treat malaria? Chloroquine was
once the drug of choice. It was an amazing
wonder drug that could get rid of malaria
instantly. The way it works, is it blocks
heme detoxification in red blood cells, so
when the parasites are replicating in red
blood cells, they want to break apart heme
and to get the iron part out, the heme itself
is toxic, the malaria wants to break it down.
This drug prevents that detoxification, that
results in killing of the parasite. However
the use of this drug over many years led to
extensive resistance, so it's not really useful
anymore. Fortunately, we do have other drugs
like mefloquine, malarone, quinine, halofantrine
and the artemisins. The latter, very effective
drugs, can be modified in ways to make derivatives,
recently their discovery was recognized with
the Nobel Prize.