Plasmodium Malariae: Treatment

by Vincent Racaniello, PhD

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    00:01 Natural infection, natural immunity to infection, is imperfect. You are not protected, even though you do respond, you are not protected against reinfection. So this is the hallmark of malaria. Throughout your whole life, if you live in an endemic area, you will be reinfected over and over and over again. And as I said, this leads to a miserable life in which you can't do anything productive.

    00:29 How do you treat malaria? Chloroquine was once the drug of choice. It was an amazing wonder drug that could get rid of malaria instantly. The way it works, is it blocks heme detoxification in red blood cells, so when the parasites are replicating in red blood cells, they want to break apart heme and to get the iron part out, the heme itself is toxic, the malaria wants to break it down. This drug prevents that detoxification, that results in killing of the parasite. However the use of this drug over many years led to extensive resistance, so it's not really useful anymore. Fortunately, we do have other drugs like mefloquine, malarone, quinine, halofantrine and the artemisins. The latter, very effective drugs, can be modified in ways to make derivatives, recently their discovery was recognized with the Nobel Prize.

    About the Lecture

    The lecture Plasmodium Malariae: Treatment by Vincent Racaniello, PhD is from the course Parasites.

    Included Quiz Questions

    1. It blocks heme detoxification in red blood cells
    2. It blocks H2O2 production
    3. It blocks the G6PD enzyme
    4. It acts as a precursor of Glutathione
    5. It blocks dihydrofolate reductase
    1. Iron
    2. Haem
    3. Globulin
    4. Mitochondria
    5. Cell adhesion glycoproteins

    Author of lecture Plasmodium Malariae: Treatment

     Vincent Racaniello, PhD

    Vincent Racaniello, PhD

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