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Lymphadenopathy: Plasmacytomam, MGUS and Lymphoplasmacytic Lymphoma – White Blood Cell Pathology

by Carlo Raj, MD
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    Our topic here is plasmacytoma. Plasmacytoma could be solitary, a lesion, consisting of once again monoclonal neoplasm to the plasma cell. So we have a monoclonal gammopathy. With solitary, one lesion would be perhaps in the bone marrow, intramedullary. Or if it’s extramedullary, the number one location for extramedullary type of plasmacytoma, solitary type, would be the upper respiratory tract. Solitary lesion type of plasmacytoma, bone marrow, extramedullary, upper respiratory tract. And you have bony plasmacytomas, usually eventually present into or lead into multiple myeloma 10-20 years down the road, okay? So you have your solitary lesion or solitary plasmacytoma which could be intramedullary or could be extramedullary. And then the bony plasmacytomas may then go on to multiple myeloma decades down the road. Extraosseous plasmacytomas rarely progress and can often be surgically cured. Okay, make sure that you know the different patterns of plasmacytomas as once again you have a monoclonal gammopathy from the plasma cell but it could be solitary. It could be within intramedullary, extramedullary. It could be bony or could be extraosseous, which could be surgically cured. Our topic here is MGUS, which stands for monoclonal gammopathy of undetermined significance. So yet, we have another monoclonal gammopathy. You have an M protein. Oh, boy. So this would rather seem like it would be multiple myeloma. You actually find IgG or IgA. But guess what? Luckily with MGUS, there are no other bony infiltrative type of symptoms in your patient. Okay, so there is no bone pain. And as far as signs, no pathologic fractures. There is no hypercalcemia, no hypocalciuria, so on and so forth. Found in 1% of people greater than 50. Incidence would increase with age. And only a small percentage may then go on to multiple myeloma. So MGUS, quite common, it is...

    About the Lecture

    The lecture Lymphadenopathy: Plasmacytomam, MGUS and Lymphoplasmacytic Lymphoma – White Blood Cell Pathology by Carlo Raj, MD is from the course Lymphadenopathy – White Blood Cell Pathology (WBC).


    Included Quiz Questions

    1. Upper respiratory tract
    2. Lower respiratory tract
    3. Ribs
    4. Bone marrow
    5. Thoracic and lumbar vertebral
    1. Monoclonal gammopathy of undetermined significance
    2. Extramedullary plasmacytoma
    3. Lymphoma
    4. Multiple myeloma
    5. Solitary plasmacytoma of bone
    1. Punched out lesions
    2. Gamma spike with IgG
    3. M protein
    4. Gamma spike with IgA
    5. Monoclonal paraprotein band
    1. Waldenstrom macroglobulinemia
    2. Hodgkin lymphoma
    3. Solitary plasmacytomas
    4. Non-Hodgkin lymphoma
    5. Multiple myeloma
    1. Bony lytic lesions
    2. Anemia
    3. Thrombocytopenia
    4. Lymphadenopathy
    5. Hepatomegaly

    Author of lecture Lymphadenopathy: Plasmacytomam, MGUS and Lymphoplasmacytic Lymphoma – White Blood Cell Pathology

     Carlo Raj, MD

    Carlo Raj, MD


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