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Pharmacology Question Set 3

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    About the Lecture

    The lecture Pharmacology Question Set 3 by Lecturio USMLE is from the course Pharmacology – Board-Style Questions.


    Included Quiz Questions

    1. Inhibition of serotonin receptors on the vagal and spinal afferent nerves from the intestines
    2. Stimulation of 5-HT3 receptors on the nucleus of the tractus solitarius
    3. Stimulation of intestinal and colonic motility
    4. Inhibition of gastroesophageal motility
    5. Inhibition of dopamine receptors on chemoreceptor trigger zone (CTZ)
    1. Inhibition of dopamine receptors in the area postrema
    2. Inhibition of serotonin receptors on the nucleus tractus solitarius
    3. Stimulation of motilin receptors in gastrointestinal smooth muscle
    4. Enhancement of small intestinal and colonic motility by dopamine antagonism
    5. Decreased esophageal peristaltic amplitude
    1. Inhibition of dopamine receptors in the area postrema
    2. Inhibition of serotonin receptors on the nucleus tractus solitarius
    3. Stimulation of motilin receptors in gastrointestinal smooth muscle
    4. Enhancement of small intestinal and colonic motility by dopamine antagonism
    5. Decreased esophageal peristaltic amplitude
    1. Inhibition of thymidylate synthase
    2. Inhibition of dihydrofolate reductase
    3. Inhibition of de novo purine nucleotide synthesis
    4. Inhibition of ribonucleotide reductase
    5. Inhibition of DNA repair
    1. Formation of interstrand DNA cross-links
    2. Free radical-mediated lipid peroxidation
    3. Inhibition of polymerization of tubulin
    4. Inhibition of topoisomerase I
    5. Inhibition of topoisomerase II
    1. A single dose of Td vaccine at 18 years of age
    2. A single dose of TdaP vaccine right now
    3. A single dose of TdaP vaccine at 13 years of age
    4. A single dose of TdaP vaccine at 18 years of age
    5. A single dose of Td vaccine right now
    1. Conjugation with a protein carrier provides effective protection to infants
    2. Polysaccharides conjugated with proteins are T cell-independent antigens
    3. Conjugation with a protein carrier generates IgM-dominant antibody responses
    4. Conjugation with a protein carrier generates IgG2-dominant antibody responses
    5. Conjugation with a protein carrier improves vaccine stability
    1. Digoxin antibody
    2. Atropine
    3. Procainamide
    4. Propranolol
    5. Quinidine
    1. Myasthenia gravis
    2. Constipation
    3. Sensorineural deafness
    4. Weight gain
    5. Pulmonary fibrosis
    1. Fomepizole
    2. Dimercaprol
    3. Flumazenil
    4. Methylene blue
    5. Succimer
    1. Phytonadione
    2. Fresh frozen plasma
    3. Menaquinone
    4. Protamine sulfate
    5. Recombinant factor VIIa
    1. Promotes microcirculatory blood flow
    2. Promotes fecal excretion of unabsorbed acetaminophen
    3. Prevents gastrointestinal absorption of acetaminophen
    4. Promotes glucuronidation of unmetabolized acetaminophen
    5. Promotes oxidation of N-acetyl-p-benzoquinoneimine (NAPQI)
    1. She is likely over-exerted and taking the herbal supplements has no proven medical benefit.
    2. She should not take St. John's wort because of potential drug interactions with antidepressants.
    3. She should start with the herbal product and come back if her energy level does not improve in two weeks.
    4. She should increase her diet so that she has more energy to go about her day.
    5. She is taking excessive vitamin C and it's causing her lowered energy levels.
    1. Systolic blood pressure of 200 mmHg
    2. A platelet count of 130,000/mm^3
    3. Cholesterol level of 240 mg/dl
    4. Age of 74 years
    5. Creatinine level of 1.3 mg/dl
    1. IPV is known to produce higher titers of serum IgG antibodies than OPV
    2. IPV is known to produce higher titers of mucosal IgG antibodies than OPV
    3. IPV is known to produce higher titers of mucosal IgA antibodies than OPV
    4. IPV is known to produce virus-specific CD8+ T cells that directly kills polio-infected cells
    5. IPV is known to produce virus-specific CD4+ T cells that produce interleukins and interferons to control polio viruses
    1. LAV requires stricter requirements for cold chain maintenance as compared to a subunit vaccine.
    2. LAV produces poorer immunological memory than a subunit vaccine as the later contains only specific immunogenic antigens.
    3. LAV has an less potential for immunization errors as compared to a subunit vaccine.
    4. LAV is equally safe as a subunit vaccine for administration to a pregnant woman.
    5. LAV cannot cause symptomatic infection in a immunocompetent person and therefore is as safe as a subunit vaccine.
    1. Prolonged bleeding time
    2. Prolonged activated partial thromboplastin time (aPTT)
    3. Prolonged prothrombin time (PT)
    4. Decreased platelet count
    5. Increased D-dimers
    1. Vincristine
    2. Daunorubicin
    3. Prednisolone
    4. Methotrexate
    5. Pyridoxine
    1. Opioid intoxication
    2. Hypoglycemia
    3. Hallucinogen toxicity
    4. Alcohol intoxication
    5. Cocaine abuse
    1. Doxorubicin
    2. Tamoxifen
    3. Radiation therapy
    4. Cyclophosphamide
    5. Myocarditis
    1. Naltrexone
    2. Ethanol
    3. Dextrose
    4. Methadone
    5. Atropine
    1. Magnesium sulfate
    2. Diazepam
    3. Ethosuximide
    4. Phenobarbital
    5. Valproic acid
    1. Prevention of binding of IgE antibodies to mast cell receptors
    2. Inhibition of synthesis of IgE antibodies
    3. Prevention of binding of interleukin-5 (IL-5) to its receptors
    4. Inhibition of synthesis of interleukin-4 (IL-4)
    5. Selective binding to interleukin-3 (IL-3) and inhibition of its actions
    1. Hoarseness of voice
    2. Short stature
    3. Posterior subcapsular cataract
    4. Suppression of HPA (hypothalamus-pituitary-adrenal) axis
    5. Steroid psychosis
    1. Inhaled cromolyn sodium
    2. Oral theophylline
    3. Inhaled ipratropium bromide
    4. Subcutaneous terbutaline
    5. Oral roflumilast
    1. Inhibition of vagally mediated contraction of bronchial smooth muscles
    2. Inhibition of degranulation of mast cells
    3. Inhibition of phosphodiesterase 4 leading to prevention of release of cytokines and chemokines
    4. Inhibition of adenosine receptors in respiratory tract
    5. Inhibition of vagally mediated dryness in respiratory mucosa
    1. Headache and tinnitus
    2. Pulmonary fibrosis and corneal deposits
    3. Hypothyroidism and phototoxicity
    4. Dyslipidemia and hypoglycemia unawareness
    5. Pedal edema and flushing
    1. Presence of anti-histone antibodies
    2. Decreased serum C3
    3. Decreased serum C4
    4. Presence of anti-dsDNA antibodies
    5. Presence of anti-Sm antibodies
    1. Bilateral pedal edema
    2. Bloody diarrhea
    3. Stevens-Johnson syndrome
    4. Hypoglycemia
    5. Multifocal atrial tachycardia
    1. Bronchospasm
    2. Pallor
    3. Tachycardia
    4. Muscle cramps
    5. Hypertension
    1. Drug A will not decrease blood pressure, regardless of its dose or supplementation of B or E
    2. Drug A will decrease blood pressure in same dose as required for patients with health liver
    3. Increased dose of drug A will be required to decrease blood pressure
    4. Drug A will decrease blood pressure only if reactant B is also supplemented in necessary dose
    5. Drug A will decrease blood pressure only if enzyme E is also supplemented in necessary dose
    1. Acidic pH, co-administration of antioxidant A, no administration of drug B
    2. Physiologic pH, co-administration of antioxidant A and of drug B
    3. Physiologic pH, co-administration of antioxidant A, no administration of drug B
    4. Physiologic pH, co-administration of drug B, no administration of antioxidant A
    5. Physiologic pH only, without administration of antioxidant A or of drug B
    1. Value of Vmax is unchanged but value of Km is increased
    2. Value of Vmax is decreased but value of Km is increased
    3. Value of Vmax is decreased but value of Km is unchanged
    4. Values of both Vmax and Km are decreased
    5. Values of both Vmax and Km are unchanged
    1. Daily consumption of grapefruit juice
    2. Daily consumption of St. John’s wort
    3. Daily consumption of charcoal-broiled foods
    4. Daily consumption of cruciferous vegetables
    5. Daily consumption of tomatoes
    1. Warfarin
    2. Apixaban
    3. Dabigatran
    4. Enoxaparin
    5. Fondaparinux
    1. Atenolol
    2. Acebutolol
    3. Celiprolol
    4. Penbutolol
    5. Pindolol
    1. Prolongation of cardiac depolarization by blocking the potassium channels
    2. Prolongation of action potential duration by blocking the rapid outward sodium current
    3. Suppression of phase 4 upstroke in the myocardial fibers by slowly dissociating from sodium channels
    4. Slowing the rapid upstroke during phase 0 by blocking the calcium channels
    5. Prolongation of the atrial effective refractory period by blocking IACh and Ito currents
    1. Induction of CYP3A4 by rifampin leading to decreased serum levels of ethinyl estradiol and progesterone
    2. Induction of CYP2A6 by rifampin leading to increased inactivation of ethinyl estradiol
    3. Induction of CYP2E1 by isoniazid leading to decreased serum levels of progesterone
    4. Interference with intestinal absorption of oral contraceptive by pyrazinamide
    5. Increased renal elimination of progesterone component of oral contraceptive by ethambutol
    1. Cimetidine
    2. Famotidine
    3. Ranitidine
    4. Omeprazole
    5. Pantoprazole
    1. Amiodarone inhibits CYP2C9 leading to increased risk of bleeding
    2. Amiodarone decreases the renal tubular secretion of warfarin leading to increased risk of bleeding
    3. Amiodarone induces CYP3A4 leading to decreased effectiveness of warfarin
    4. Amiodarone causes hepatotoxicity which requires monitoring of prothrombin time
    5. Inorganic iodine from amiodarone decreases effectiveness of warfarin
    1. Synergism of aztreonam with tobramycin
    2. Effective combination of a bactericidal and a bacteriostatic antimicrobial against Pseudomonas aeruginosa
    3. Broad-spectrum coverage against anaerobes by adding tobramycin to aztreonam
    4. Broad-spectrum coverage against gram positive cocci by adding tobramycin to aztreonam
    5. Reduction of the side-effects of both aztreonam and tobramycin
    1. Norepinephrine has less β2-adrenergic effects compared to epinephrine
    2. Norepinephrine has less α1-adrenergic activity compared to epinephrine
    3. Norepinephrine has more α2-adrenergic effects compared to epinephrine
    4. Norepinephrine has less β1-adrenergic effects compared to epinephrine
    5. Norepinephrine has more β2-adrenergic effects compared to epinephrine
    1. GqPCRs (Gq-protein coupled receptors)
    2. GsPCRs (Gs-protein coupled receptors)
    3. GiPCRs (Gi-protein coupled receptors)
    4. GoPCRs (Go-protein coupled receptors)
    5. GtPCRs (Gt-protein coupled receptors)
    1. Cyclic adenosine monophosphate (cAMP)
    2. Cyclic guanosine monophosphate (cGMP)
    3. Inositol 1,4,5-triphosphate (IP3)
    4. Diacylglycerol (DAG)
    5. Calcium ion
    1. Contraction of the pupillary dilator muscle with no effect on the ciliary muscle
    2. Relaxation of the pupillary sphincter muscle with contraction of the ciliary muscle
    3. Contraction of the pupillary sphincter muscle with no effect on the ciliary muscle
    4. Relaxation of the pupillary sphincter muscle with no effect on the ciliary muscle
    5. Relaxation of the pupillary dilator muscle with no effect on the ciliary muscle
    1. Decreased peripheral sympathetic outflow
    2. Decreased renin release from the kidneys leading to decreased activation of renin-angiotensin-aldosterone (RAA) system
    3. Negative inotropic effect on the heart
    4. Vasodilation of peripheral arteries
    5. Vasodilation of peripheral veins
    1. Sodium bicarbonate
    2. Diazepam
    3. Induced vomiting
    4. Lidocaine
    5. Norepinephrine
    1. Blockage of alpha-1 adrenergic receptors
    2. Decreased reuptake of serotonin
    3. Decreased reuptake of norepinephrine
    4. Blockage of H1 histamine receptors
    5. Blockage of muscarinic receptors
    1. Continue sertraline
    2. Discontinue sertraline
    3. Add fluoxetine to sertraline
    4. Add amitriptyline to sertraline
    5. Replace sertraline with fluoxetine
    1. Missed dose of venlafaxine
    2. Aspirin overdose
    3. Dehydration due to physical activity
    4. Ischemic stroke
    5. Missed dose of lisinopril
    1. Venlafaxine
    2. Amitriptyline
    3. Clonidine
    4. Paroxetine
    5. Phenylephrine
    1. Blood pressure
    2. Aspartate aminotransferase
    3. Creatine phosphokinase
    4. Serum creatinine
    5. Temperature
    1. History of bulimia nervosa
    2. Age of 22 years
    3. Esomeprazole usage
    4. BMI of 24 kg/m^2
    5. Smoking cessation
    1. Bupropion
    2. Nortriptyline
    3. Buspirone
    4. Fluoxetine
    5. Phenelzine
    1. Mirtazapine
    2. Amitriptyline
    3. Bupropion
    4. Fluoxetine
    5. Trazodone
    1. Trazodone
    2. Paroxetine
    3. Zolpidem
    4. St. John's Wort
    5. Diazepam
    1. Methylphenidate
    2. Alprazolam
    3. Continuous Positive Airway Pressure (CPAP)
    4. Melatonin
    5. Orlistat
    1. Triazolam
    2. Buspirone
    3. Hydroxyzine
    4. Thiopental
    5. Propranolol
    1. Atomoxetine
    2. Diazepam
    3. Sertraline
    4. Methylphenidate
    5. Olazapine

    Author of lecture Pharmacology Question Set 3

     Lecturio USMLE

    Lecturio USMLE


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